Title |
Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease
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Published in |
Molecular Neurodegeneration, September 2012
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DOI | 10.1186/1750-1326-7-49 |
Pubmed ID | |
Authors |
Paula Desplats, Pruthul Patel, Kori Kosberg, Michael Mante, Christina Patrick, Edward Rockenstein, Masayo Fujita, Makoto Hashimoto, Eliezer Masliah |
Abstract |
Parkinson's disease (PD) is a multifactorial disease where environmental factors act on genetically predisposed individuals. Although only 5% of PD manifestations are associated with specific mutations, majority of PD cases are of idiopathic origin, where environment plays a prominent role. Concurrent exposure to Paraquat (PQ) and Maneb (MB) in rural workers increases the risk for PD and exposure of adult mice to MB/PQ results in dopamine fiber loss and decreased locomotor activity. While PD is characterized by neuronal loss in the substantia nigra, we previously showed that accumulation of α-synuclein in the limbic system contributes to neurodegeneration by interfering with adult neurogenesis. |
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