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The significance of circulating epithelial cells in Breast Cancer patients by a novel negative selection method

Overview of attention for article published in Breast Cancer Research and Treatment, December 2007
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

patent
1 patent
wikipedia
1 Wikipedia page

Citations

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23 Dimensions

Readers on

mendeley
15 Mendeley
citeulike
1 CiteULike
Title
The significance of circulating epithelial cells in Breast Cancer patients by a novel negative selection method
Published in
Breast Cancer Research and Treatment, December 2007
DOI 10.1007/s10549-007-9771-9
Pubmed ID
Authors

Katherine H. Rak Tkaczuk, Olga Goloubeva, Nancy S. Tait, Faye Feldman, Ming Tan, Zhao-Ping Lum, Stephen A. Lesko, David A. Van Echo, Paul O. P. Ts’o

Abstract

A negative selection method for the enumeration and characterization of circulating epithelial/cancer cells (CCC) in Breast Cancer (BC) patients is described. This manual procedure yields reproducible results of high sensitivity and selectivity suitable for research laboratories. We conducted a prospective blood sampling study in 105 women with stage 1-4 BC attending clinics at the University of Maryland Greenebaum Cancer Center to define the prevalence of CCC utilizing our sensitive double gradient centrifugation and magnetic cell sorting CCC detection and enumeration method. CCC were isolated and enumerated from 15 to 20 ml of venous blood drawn before the start of systemic therapy and periodically thereafter for up to 24 months. One or more CCC/sample was considered a positive result. We analyzed 487 samples for the presence of CCC; the median number of samples/patient was 4 (range 1-8). CCC were detected in 56% of patients, 19%-stage 1; 43%-stage 2; 46%-stage 3; 83%-stage 4. The probability of being positive for the presence of CCC is significantly associated with the stage of cancer (P < 0.0001). The frequency of CCC positive patients and samples increased with the advancing stage of disease. Presence of more than 10 CCC/sample was associated with the decreased survival and increased probability of having metastatic disease P = 0.001. Increasing number of CCC/sample correlates with the adverse outcome and poorer survival (P < 0.0001). Our CCC test based on the negative selection procedure may provide valuable prognostic information.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 7%
Unknown 14 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 40%
Researcher 4 27%
Student > Master 2 13%
Professor 1 7%
Lecturer > Senior Lecturer 1 7%
Other 1 7%
Readers by discipline Count As %
Medicine and Dentistry 5 33%
Agricultural and Biological Sciences 4 27%
Engineering 3 20%
Physics and Astronomy 1 7%
Chemistry 1 7%
Other 1 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 August 2016.
All research outputs
#2,126,056
of 12,334,049 outputs
Outputs from Breast Cancer Research and Treatment
#467
of 3,102 outputs
Outputs of similar age
#62,373
of 266,404 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#18
of 107 outputs
Altmetric has tracked 12,334,049 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,102 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,404 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 107 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.