| Title |
Vertebrate cardiac regeneration: evolutionary and developmental perspectives
|
|---|---|
| Published in |
Cell Regeneration, March 2021
|
| DOI | 10.1186/s13619-020-00068-y |
| Pubmed ID | |
| Authors |
Stephen Cutie, Guo N. Huang |
| Abstract |
Cardiac regeneration is an ancestral trait in vertebrates that is lost both as more recent vertebrate lineages evolved to adapt to new environments and selective pressures, and as members of certain species developmentally progress towards their adult forms. While higher vertebrates like humans and rodents resolve cardiac injury with permanent fibrosis and loss of cardiac output as adults, neonates of these same species can fully regenerate heart structure and function after injury - as can adult lower vertebrates like many teleost fish and urodele amphibians. Recent research has elucidated several broad factors hypothesized to contribute to this loss of cardiac regenerative potential both evolutionarily and developmentally: an oxygen-rich environment, vertebrate thermogenesis, a complex adaptive immune system, and cancer risk trade-offs. In this review, we discuss the evidence for these hypotheses as well as the cellular participators and molecular regulators by which they act to govern heart regeneration in vertebrates. |
X Demographics
The data shown below were collected from the profiles of 76 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 35 | 46% |
| Australia | 3 | 4% |
| United Kingdom | 3 | 4% |
| Japan | 2 | 3% |
| Canada | 2 | 3% |
| China | 2 | 3% |
| Hong Kong | 1 | 1% |
| Spain | 1 | 1% |
| Norway | 1 | 1% |
| Other | 6 | 8% |
| Unknown | 20 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 39 | 51% |
| Members of the public | 34 | 45% |
| Practitioners (doctors, other healthcare professionals) | 2 | 3% |
| Science communicators (journalists, bloggers, editors) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 32 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 19% |
| Student > Bachelor | 4 | 13% |
| Student > Master | 4 | 13% |
| Other | 3 | 9% |
| Researcher | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 10 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 11 | 34% |
| Agricultural and Biological Sciences | 3 | 9% |
| Engineering | 2 | 6% |
| Medicine and Dentistry | 2 | 6% |
| Nursing and Health Professions | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 12 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 47. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2023.
All research outputs
#900,984
of 25,635,728 outputs
Outputs from Cell Regeneration
#4
of 192 outputs
Outputs of similar age
#25,635
of 453,373 outputs
Outputs of similar age from Cell Regeneration
#1
of 11 outputs
Altmetric has tracked 25,635,728 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 192 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 453,373 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.