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In vitro investigation of Debaryomyces hansenii strains for potential probiotic properties

Overview of attention for article published in World Journal of Microbiology & Biotechnology, July 2016
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Title
In vitro investigation of Debaryomyces hansenii strains for potential probiotic properties
Published in
World Journal of Microbiology & Biotechnology, July 2016
DOI 10.1007/s11274-016-2109-1
Pubmed ID
Authors

Honeylet Sabas Ochangco, Amparo Gamero, Ida M. Smith, Jeffrey E. Christensen, Lene Jespersen, Nils Arneborg

Abstract

In this study, 23 Debaryomyces hansenii strains, isolated from cheese and fish gut, were investigated in vitro for potential probiotic properties i.e. (1) survival under in vitro GI (gastrointestinal) conditions with different oxygen levels, (2) adhesion to Caco-2 intestinal epithelial cells and mucin, and (3) modulation of pro- and anti-inflammatory cytokine secretion by human monocyte-derived dendritic cells. As references two commercially available probiotic Saccharomyces cerevisiae var. boulardii (S. boulardii) strains were included in the study. Our results demonstrate that the different D. hansenii yeast strains had very diverse properties which could potentially lead to different probiotic effects. One strain of D. hansenii (DI 09) was capable of surviving GI stress conditions, although not to the same degree as the S. boulardii strains. This DI 09 strain, however, adhered more strongly to Caco-2 cells and mucin than the S. boulardii strains. Additionally, two D. hansenii strains (DI 10 and DI 15) elicited a higher IL-10/IL-12 ratio than the S. boulardii strains, indicating a higher anti-inflammatory effects on human dendritic cells. Finally, one strain of D. hansenii (DI 02) was evaluated as the best probiotic candidate because of its outstanding ability to survive the GI stresses, to adhere to Caco-2 cells and mucin and to induce a high IL-10/IL-12 ratio. In conclusion, this study shows that strains of D. hansenii may offer promising probiotic traits relevant for further study.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 5 19%
Student > Bachelor 5 19%
Student > Master 4 15%
Researcher 3 12%
Student > Ph. D. Student 2 8%
Other 7 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 35%
Unspecified 7 27%
Biochemistry, Genetics and Molecular Biology 4 15%
Veterinary Science and Veterinary Medicine 2 8%
Nursing and Health Professions 2 8%
Other 2 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2016.
All research outputs
#10,937,138
of 12,340,632 outputs
Outputs from World Journal of Microbiology & Biotechnology
#747
of 991 outputs
Outputs of similar age
#221,948
of 267,093 outputs
Outputs of similar age from World Journal of Microbiology & Biotechnology
#27
of 39 outputs
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