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Does CRP predict outcome in bipolar disorder in regular outpatient care?

Overview of attention for article published in International Journal of Bipolar Disorders, July 2016
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Title
Does CRP predict outcome in bipolar disorder in regular outpatient care?
Published in
International Journal of Bipolar Disorders, July 2016
DOI 10.1186/s40345-016-0055-3
Pubmed ID
Authors

Sonya M. Balukova, Bartholomeus C. M. Haarman, Rixt F. Riemersma-van der Lek, Robert A. Schoevers

Abstract

The association between inflammation and the course of mood disorders is receiving increased attention. This study aims to investigate whether a sub-group of patients with BD can be identified for which a higher CRP (C-reactive protein) level at baseline is associated with an unfavorable prognosis. This is a historic cohort study using CRP at baseline, with 15-month follow-up of mood status and medication. Cross-sectional analyses include boxplots, one-way ANOVA, receiver operating characteristics (ROC) curve and Chi square test, and the longitudinal analysis using multivariate Cox-regression. Eighty-four bipolar disorder patients were included in the analyses. Cross-sectionally, no statistically significant difference was found in CRP distribution across mood states (p = 0.372) or rapid cycling state (p = 0.656). Also, no CRP cut-off level was distinguished between euthymic and non-euthymic patients according to the ROC curve (p = 0.449, AUC = 0.452, 95 % CI 0.327, 0.576), and a literature-derived cut-off value (3 mg/L) again demonstrated no difference (p = 0.530). Longitudinally, no association was found between CRP and prognosis of disease neither in euthymic [-2 log likelihood = 120.460; CRP: p = 0.866, B = -0.011, OR = 0.989 (95 % CI 0.874-1.120)] nor non-euthymic patients [(-2 log likelihood = 275.028; CRP: p = 0.802, B = 0.010, OR = 1.010 (95 % CI 0.937-1.088)]. Medication use did not affect these associations. We found no statistically significant association between CRP and a more unfavorable BD prognosis, suggesting that the application of CRP as a practical biomarker to predict outcome in a naturalistic outpatient care setting is not as straightforward as it may seem.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 3%
Unknown 34 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 20%
Other 5 14%
Researcher 5 14%
Student > Ph. D. Student 3 9%
Student > Master 3 9%
Other 6 17%
Unknown 6 17%
Readers by discipline Count As %
Medicine and Dentistry 10 29%
Neuroscience 5 14%
Psychology 3 9%
Agricultural and Biological Sciences 2 6%
Nursing and Health Professions 2 6%
Other 5 14%
Unknown 8 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2016.
All research outputs
#18,466,238
of 22,881,154 outputs
Outputs from International Journal of Bipolar Disorders
#230
of 285 outputs
Outputs of similar age
#279,112
of 363,150 outputs
Outputs of similar age from International Journal of Bipolar Disorders
#4
of 4 outputs
Altmetric has tracked 22,881,154 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 285 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.1. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 363,150 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.