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Detection of murine post-pneumonectomy lung regeneration by 18FDG PET imaging

Overview of attention for article published in EJNMMI Research, September 2012
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  • High Attention Score compared to outputs of the same age and source (81st percentile)

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Title
Detection of murine post-pneumonectomy lung regeneration by 18FDG PET imaging
Published in
EJNMMI Research, September 2012
DOI 10.1186/2191-219x-2-48
Pubmed ID
Authors

Barry C Gibney, Mi-Ae Park, Kenji Chamoto, Alexandra Ysasi, Moritz A Konerding, Akira Tsuda, Steven J Mentzer

Abstract

An intriguing biologic process in most adult mammals is post-pneumonectomy lung regeneration, that is, the removal of one lung (pneumonectomy) results in the rapid compensatory growth of the remaining lung. The spatial dependence and metabolic activity of the rodent lung during compensatory lung regeneration is largely unknown. To determine if murine lung regeneration could be detected in vivo, we studied inbred mice 3, 7, 14, and 21 days after left pneumonectomy. The remaining lung was imaged using microCT as well as the glucose tracer 2-deoxy-2-[18 F]fluoro-d-glucose (18FDG) and positron-emission tomography (PET). Because of the compliance of the murine chest wall, reproducible imaging required orotracheal intubation and pressure-controlled ventilation during scanning. After left pneumonectomy, the right lung progressively enlarged over the first 3 weeks. The cardiac lobe demonstrated the greatest percentage increase in size. Dry weights of the individual lobes largely mirrored the increase in lung volume. PET/CT imaging was used to identify enhanced metabolic activity within the individual lobes. In the cardiac lobe, 18FDG uptake was significantly increased in the day 14 cardiac lobe relative to preoperative values (p < .05). In contrast, the 18FDG uptake in the other three lobes was not statistically significant at any time point. We conclude that the cardiac lobe is the dominant contributor to compensatory growth after murine pneumonectomy. Further, PET/CT scanning can detect both the volumetric increase and the metabolic changes associated with the regenerative growth in the murine cardiac lobe.

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Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 28%
Student > Master 3 17%
Student > Ph. D. Student 3 17%
Other 1 6%
Student > Bachelor 1 6%
Other 1 6%
Unknown 4 22%
Readers by discipline Count As %
Medicine and Dentistry 6 33%
Agricultural and Biological Sciences 4 22%
Biochemistry, Genetics and Molecular Biology 2 11%
Engineering 2 11%
Unknown 4 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2012.
All research outputs
#18,316,001
of 22,679,690 outputs
Outputs from EJNMMI Research
#335
of 555 outputs
Outputs of similar age
#129,659
of 170,728 outputs
Outputs of similar age from EJNMMI Research
#2
of 11 outputs
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So far Altmetric has tracked 555 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
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