| Title |
Chlorophyll Revisited: Anti-inflammatory Activities of Chlorophyll a and Inhibition of Expression of TNF-α Gene by the Same
|
|---|---|
| Published in |
Inflammation, October 2011
|
| DOI | 10.1007/s10753-011-9399-0 |
| Pubmed ID | |
| Authors |
Appian Subramoniam, Velikkakathu V. Asha, Sadasivan Ajikumaran Nair, Sreejith P. Sasidharan, Parameswaran K. Sureshkumar, Krishnan Nair Rajendran, Devarajan Karunagaran, Krishnan Ramalingam |
| Abstract |
In view of the folklore use of green leaves to treat inflammation, the anti-inflammatory property of chlorophylls and their degradation products were studied. Chlorophyll a and pheophytin a (magnesium-free chlorophyll a) from fresh leaves showed potent anti-inflammatory activity against carrageenan-induced paw edema in mice and formalin-induced paw edema in rats. Chlorophyll a inhibited bacterial lipopolysaccharide-induced TNF-α (a pro-inflammatory cytokine) gene expression in HEK293 cells, but it did not influence the expression of inducible nitric acid synthase and cyclooxygenase-2 genes. Chlorophyll b only marginally inhibited both inflammation and TNF-α gene expression. But both chlorophyll a and chlorophyll b showed the same level of marginal inhibition on 12-O-tetradecanoyl-phorbol-13-acetate-induced NF-κB activation. Chlorophylls and pheophytins showed in vitro anti-oxidant activity. The study shows that chlorophyll a and its degradation products are valuable and abundantly available anti-inflammatory agents and promising for the development of phytomedicine or conventional medicine to treat inflammation and related diseases. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 1% |
| Unknown | 97 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 18 | 18% |
| Student > Master | 12 | 12% |
| Researcher | 11 | 11% |
| Student > Ph. D. Student | 8 | 8% |
| Student > Postgraduate | 5 | 5% |
| Other | 14 | 14% |
| Unknown | 30 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 22% |
| Biochemistry, Genetics and Molecular Biology | 10 | 10% |
| Medicine and Dentistry | 9 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Chemistry | 4 | 4% |
| Other | 12 | 12% |
| Unknown | 36 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 49. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2022.
All research outputs
#749,711
of 23,275,636 outputs
Outputs from Inflammation
#5
of 1,067 outputs
Outputs of similar age
#3,042
of 141,772 outputs
Outputs of similar age from Inflammation
#1
of 6 outputs
Altmetric has tracked 23,275,636 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,067 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done particularly well, scoring higher than 99% of its peers.
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