↓ Skip to main content

Chlorophyll Revisited: Anti-inflammatory Activities of Chlorophyll a and Inhibition of Expression of TNF-α Gene by the Same

Overview of attention for article published in Inflammation, October 2011
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#13 of 732)
  • High Attention Score compared to outputs of the same age (90th percentile)

Mentioned by

1 blog
2 tweeters
1 patent
2 video uploaders


43 Dimensions

Readers on

47 Mendeley
1 CiteULike
Chlorophyll Revisited: Anti-inflammatory Activities of Chlorophyll a and Inhibition of Expression of TNF-α Gene by the Same
Published in
Inflammation, October 2011
DOI 10.1007/s10753-011-9399-0
Pubmed ID

Appian Subramoniam, Velikkakathu V. Asha, Sadasivan Ajikumaran Nair, Sreejith P. Sasidharan, Parameswaran K. Sureshkumar, Krishnan Nair Rajendran, Devarajan Karunagaran, Krishnan Ramalingam


In view of the folklore use of green leaves to treat inflammation, the anti-inflammatory property of chlorophylls and their degradation products were studied. Chlorophyll a and pheophytin a (magnesium-free chlorophyll a) from fresh leaves showed potent anti-inflammatory activity against carrageenan-induced paw edema in mice and formalin-induced paw edema in rats. Chlorophyll a inhibited bacterial lipopolysaccharide-induced TNF-α (a pro-inflammatory cytokine) gene expression in HEK293 cells, but it did not influence the expression of inducible nitric acid synthase and cyclooxygenase-2 genes. Chlorophyll b only marginally inhibited both inflammation and TNF-α gene expression. But both chlorophyll a and chlorophyll b showed the same level of marginal inhibition on 12-O-tetradecanoyl-phorbol-13-acetate-induced NF-κB activation. Chlorophylls and pheophytins showed in vitro anti-oxidant activity. The study shows that chlorophyll a and its degradation products are valuable and abundantly available anti-inflammatory agents and promising for the development of phytomedicine or conventional medicine to treat inflammation and related diseases.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 2%
Unknown 46 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 26%
Researcher 9 19%
Student > Master 6 13%
Student > Ph. D. Student 3 6%
Professor 3 6%
Other 9 19%
Unknown 5 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 26%
Medicine and Dentistry 8 17%
Biochemistry, Genetics and Molecular Biology 5 11%
Pharmacology, Toxicology and Pharmaceutical Science 4 9%
Chemistry 4 9%
Other 7 15%
Unknown 7 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2019.
All research outputs
of 14,137,367 outputs
Outputs from Inflammation
of 732 outputs
Outputs of similar age
of 130,390 outputs
Outputs of similar age from Inflammation
of 1 outputs
Altmetric has tracked 14,137,367 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 732 research outputs from this source. They receive a mean Attention Score of 1.9. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 130,390 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them