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Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation

Overview of attention for article published in Current Allergy and Asthma Reports, July 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

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5 tweeters

Citations

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35 Dimensions

Readers on

mendeley
46 Mendeley
Title
Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation
Published in
Current Allergy and Asthma Reports, July 2016
DOI 10.1007/s11882-016-0634-5
Pubmed ID
Authors

Ueki, Shigeharu, Tokunaga, Takahiro, Fujieda, Shigeharu, Honda, Kohei, Hirokawa, Makoto, Spencer, Lisa A, Weller, Peter F, Shigeharu Ueki, Takahiro Tokunaga, Shigeharu Fujieda, Kohei Honda, Makoto Hirokawa, Lisa A. Spencer, Peter F. Weller

Abstract

The traditional paradigm of eosinophils as end-stage damaging cells has mainly relied on their release of cytotoxic proteins. Cytokine-induced cell survival and secretion of granular contents from tissue-dwelling eosinophil are thought to be important mechanisms for eosinophilic inflammatory disorders, although the occurrence of cytolysis and its products (i.e., free extracellular granules) has been observed in affected lesions. Recent evidence indicates that activated eosinophils can exhibit a non-apoptotic cell death pathway, namely extracellular trap cell death (ETosis) that mediates the eosinophil cytolytic degranulation. Here, we discuss the current concept of eosinophil ETosis which provides a new look at eosinophilic inflammation. Lessons from eosinophilic chronic rhinosinusitis revealed that ETosis-derived DNA traps, composed of stable web-like chromatin, contribute to the properties of highly viscous eosinophilic mucin and impairments in its clearance. Intact granules entrapped in DNA traps are causing long-lasting inflammation but also might have immunoregulatory roles. Eosinophils possess a way to have post-postmortem impacts on innate immunity, local immune response, sterile inflammation, and tissue damage.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 22%
Student > Bachelor 8 17%
Student > Ph. D. Student 7 15%
Student > Doctoral Student 6 13%
Professor 2 4%
Other 6 13%
Unknown 7 15%
Readers by discipline Count As %
Medicine and Dentistry 14 30%
Agricultural and Biological Sciences 10 22%
Immunology and Microbiology 7 15%
Biochemistry, Genetics and Molecular Biology 6 13%
Physics and Astronomy 1 2%
Other 1 2%
Unknown 7 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2017.
All research outputs
#6,079,983
of 11,522,893 outputs
Outputs from Current Allergy and Asthma Reports
#311
of 576 outputs
Outputs of similar age
#103,471
of 264,937 outputs
Outputs of similar age from Current Allergy and Asthma Reports
#6
of 15 outputs
Altmetric has tracked 11,522,893 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 576 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,937 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.