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Hsp70 chaperones: Cellular functions and molecular mechanism

Overview of attention for article published in Cellular & Molecular Life Sciences, March 2005
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#9 of 2,630)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
2 news outlets
blogs
3 blogs
twitter
1 tweeter
patent
9 patents
wikipedia
6 Wikipedia pages
googleplus
1 Google+ user

Citations

dimensions_citation
1554 Dimensions

Readers on

mendeley
1396 Mendeley
citeulike
4 CiteULike
connotea
1 Connotea
Title
Hsp70 chaperones: Cellular functions and molecular mechanism
Published in
Cellular & Molecular Life Sciences, March 2005
DOI 10.1007/s00018-004-4464-6
Pubmed ID
Authors

M. P. Mayer, B. Bukau

Abstract

Hsp70 proteins are central components of the cellular network of molecular chaperones and folding catalysts. They assist a large variety of protein folding processes in the cell by transient association of their substrate binding domain with short hydrophobic peptide segments within their substrate proteins. The substrate binding and release cycle is driven by the switching of Hsp70 between the low-affinity ATP bound state and the high-affinity ADP bound state. Thus, ATP binding and hydrolysis are essential in vitro and in vivo for the chaperone activity of Hsp70 proteins. This ATPase cycle is controlled by co-chaperones of the family of J-domain proteins, which target Hsp70s to their substrates, and by nucleotide exchange factors, which determine the lifetime of the Hsp70-substrate complex. Additional co-chaperones fine-tune this chaperone cycle. For specific tasks the Hsp70 cycle is coupled to the action of other chaperones, such as Hsp90 and Hsp100.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 1,396 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 12 <1%
Germany 9 <1%
United Kingdom 4 <1%
Brazil 4 <1%
Mexico 4 <1%
South Africa 3 <1%
Italy 3 <1%
Chile 3 <1%
Canada 2 <1%
Other 22 2%
Unknown 1330 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 365 26%
Student > Master 243 17%
Student > Bachelor 238 17%
Researcher 196 14%
Student > Doctoral Student 99 7%
Other 253 18%
Unknown 2 <1%
Readers by discipline Count As %
Agricultural and Biological Sciences 656 47%
Biochemistry, Genetics and Molecular Biology 334 24%
Unspecified 106 8%
Medicine and Dentistry 87 6%
Chemistry 61 4%
Other 150 11%
Unknown 2 <1%

Attention Score in Context

This research output has an Altmetric Attention Score of 43. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 February 2019.
All research outputs
#393,695
of 13,333,056 outputs
Outputs from Cellular & Molecular Life Sciences
#9
of 2,630 outputs
Outputs of similar age
#3,080
of 128,768 outputs
Outputs of similar age from Cellular & Molecular Life Sciences
#1
of 25 outputs
Altmetric has tracked 13,333,056 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,630 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 128,768 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.