Title |
Clinical validity of outcome pain measures in naturally occurring canine osteoarthritis
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Published in |
BMC Veterinary Research, September 2012
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DOI | 10.1186/1746-6148-8-162 |
Pubmed ID | |
Authors |
Pascale Rialland, Sylvain Bichot, Maxim Moreau, Martin Guillot, Bertrand Lussier, Dominique Gauvin, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Eric Troncy |
Abstract |
The conceptual validity of kinetic gait analysis and disability outcome assessment methods has guided their use in the assessment of pain caused by osteoarthritis (OA). No consensus on the best clinical methods for pain evaluation in canine OA exists, particularly, when evaluating treatments where a smaller treatment effect is anticipated than with pharmacological pain killers. This study thus aimed at determining the technical validity of some clinical endpoints on OA pain in dogs using the green-lipped mussel (GLM)-enriched diet.Twenty-three adult dogs with clinical OA completed the prospective controlled study. All the dogs were fed a balanced diet over a 30-day control period followed by a GLM-enriched diet over a 60-day period. The kinetic gait analysis parameter (PVF(BW), peak vertical force adjusted for body weight change), electrodermal activity (EDA), and a standardized multifactorial pain questionnaire (MFQ) were performed on day (D) 0 (inclusion), D30 (start) and D90 (end). The owners completed a client-specific outcome measures (CSOM) instrument twice a week. Motor activity (MA) was continuously recorded in seven dogs using telemetered accelerometric counts. We hypothesized that these methods would produce convergent results related to diet changes. A Type I error of 0.05 was adjusted to correct for the multiplicity of the primary clinical endpoints. |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 135 | 98% |
Demographic breakdown
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Student > Master | 16 | 12% |
Student > Bachelor | 16 | 12% |
Other | 15 | 11% |
Researcher | 14 | 10% |
Other | 23 | 17% |
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Nursing and Health Professions | 4 | 3% |
Other | 15 | 11% |
Unknown | 42 | 30% |