| Title |
A Review of Safety and Design Requirements of the Artificial Pancreas
|
|---|---|
| Published in |
Annals of Biomedical Engineering, June 2016
|
| DOI | 10.1007/s10439-016-1679-2 |
| Pubmed ID | |
| Authors |
Helga Blauw, Patrick Keith-Hynes, Robin Koops, J. Hans DeVries |
| Abstract |
As clinical studies with artificial pancreas systems for automated blood glucose control in patients with type 1 diabetes move to unsupervised real-life settings, product development will be a focus of companies over the coming years. Directions or requirements regarding safety in the design of an artificial pancreas are, however, lacking. This review aims to provide an overview and discussion of safety and design requirements of the artificial pancreas. We performed a structured literature search based on three search components-type 1 diabetes, artificial pancreas, and safety or design-and extended the discussion with our own experiences in developing artificial pancreas systems. The main hazards of the artificial pancreas are over- and under-dosing of insulin and, in case of a bi-hormonal system, of glucagon or other hormones. For each component of an artificial pancreas and for the complete system we identified safety issues related to these hazards and proposed control measures. Prerequisites that enable the control algorithms to provide safe closed-loop control are accurate and reliable input of glucose values, assured hormone delivery and an efficient user interface. In addition, the system configuration has important implications for safety, as close cooperation and data exchange between the different components is essential. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 123 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 21 | 17% |
| Student > Ph. D. Student | 18 | 15% |
| Researcher | 12 | 10% |
| Student > Master | 11 | 9% |
| Student > Doctoral Student | 9 | 7% |
| Other | 21 | 17% |
| Unknown | 32 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 32 | 26% |
| Medicine and Dentistry | 19 | 15% |
| Computer Science | 7 | 6% |
| Biochemistry, Genetics and Molecular Biology | 5 | 4% |
| Materials Science | 5 | 4% |
| Other | 22 | 18% |
| Unknown | 34 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2018.
All research outputs
#6,958,641
of 25,986,827 outputs
Outputs from Annals of Biomedical Engineering
#2
of 2 outputs
Outputs of similar age
#104,868
of 369,117 outputs
Outputs of similar age from Annals of Biomedical Engineering
#3
of 5 outputs
Altmetric has tracked 25,986,827 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 2 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one scored the same or higher as 0 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,117 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.