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Intrinsic protein disorder in histone lysine methylation

Overview of attention for article published in Biology Direct, January 2016
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2 tweeters

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60 Mendeley
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1 CiteULike
Title
Intrinsic protein disorder in histone lysine methylation
Published in
Biology Direct, January 2016
DOI 10.1186/s13062-016-0129-2
Pubmed ID
Authors

Lazar, Tamas, Schad, Eva, Szabo, Beata, Horvath, Tamas, Meszaros, Attila, Tompa, Peter, Tantos, Agnes, Tamas Lazar, Eva Schad, Beata Szabo, Tamas Horvath, Attila Meszaros, Peter Tompa, Agnes Tantos

Abstract

Histone lysine methyltransferases (HKMTs), catalyze mono-, di- and trimethylation of lysine residues, resulting in a regulatory pattern that controls gene expression. Their involvement in many different cellular processes and diseases makes HKMTs an intensively studied protein group, but scientific interest so far has been concentrated mostly on their catalytic domains. In this work we set out to analyze the structural heterogeneity of human HKMTs and found that many contain long intrinsically disordered regions (IDRs) that are conserved through vertebrate species. Our predictions show that these IDRs contain several linear motifs and conserved putative binding sites that harbor cancer-related SNPs. Although there are only limited data available in the literature, some of the predicted binding regions overlap with interacting segments identified experimentally. The importance of a disordered binding site is illustrated through the example of the ternary complex between MLL1, menin and LEDGF/p75. Our suggestion is that intrinsic protein disorder plays an as yet unrecognized role in epigenetic regulation, which needs to be further elucidated through structural and functional studies aimed specifically at the disordered regions of HKMTs. This article was reviewed by Arne Elofsson and Piotr Zielenkiewicz.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 60 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 24 40%
Student > Ph. D. Student 10 17%
Student > Bachelor 8 13%
Researcher 6 10%
Professor 3 5%
Other 4 7%
Unknown 5 8%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 33 55%
Agricultural and Biological Sciences 15 25%
Chemistry 4 7%
Computer Science 1 2%
Engineering 1 2%
Other 0 0%
Unknown 6 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2016.
All research outputs
#5,772,253
of 7,992,937 outputs
Outputs from Biology Direct
#497
of 525 outputs
Outputs of similar age
#167,794
of 260,918 outputs
Outputs of similar age from Biology Direct
#8
of 8 outputs
Altmetric has tracked 7,992,937 research outputs across all sources so far. This one is in the 24th percentile – i.e., 24% of other outputs scored the same or lower than it.
So far Altmetric has tracked 525 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
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