Title |
Ectopic discharge in Aβ afferents as a source of neuropathic pain
|
---|---|
Published in |
Experimental Brain Research, February 2009
|
DOI | 10.1007/s00221-009-1724-6 |
Pubmed ID | |
Authors |
Marshall Devor |
Abstract |
Ectopic discharge in axotomized dorsal root ganglion neurons is a key driver of neuropathic pain. However, the bulk of this activity is generated and carried centrally in large diameter myelinated Abeta afferents, a cell type that normally signals touch and vibration sense. Evidence is considered suggesting that following axotomy, Abeta afferents undergo a change in their electrical characteristics and also in the neurotransmitter complement that they express. This dual phenotypic switching renders them capable of (1) directly driving postsynaptic pain signaling pathways in the spinal cord, and (2) triggering and maintaining central sensitization. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
Portugal | 1 | <1% |
Colombia | 1 | <1% |
Canada | 1 | <1% |
Chile | 1 | <1% |
Spain | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
Unknown | 175 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 36 | 20% |
Researcher | 34 | 18% |
Student > Master | 23 | 13% |
Student > Bachelor | 21 | 11% |
Student > Doctoral Student | 9 | 5% |
Other | 31 | 17% |
Unknown | 30 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 39 | 21% |
Medicine and Dentistry | 36 | 20% |
Neuroscience | 33 | 18% |
Engineering | 11 | 6% |
Biochemistry, Genetics and Molecular Biology | 7 | 4% |
Other | 21 | 11% |
Unknown | 37 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2019.
All research outputs
#6,752,694
of 22,675,759 outputs
Outputs from Experimental Brain Research
#753
of 3,217 outputs
Outputs of similar age
#30,875
of 93,773 outputs
Outputs of similar age from Experimental Brain Research
#7
of 21 outputs
Altmetric has tracked 22,675,759 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 3,217 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,773 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.