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Mortality and pulmonary mechanics in relation to respiratory system and transpulmonary driving pressures in ARDS

Overview of attention for article published in Intensive Care Medicine, June 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

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14 X users
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3 Facebook pages

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216 Mendeley
Title
Mortality and pulmonary mechanics in relation to respiratory system and transpulmonary driving pressures in ARDS
Published in
Intensive Care Medicine, June 2016
DOI 10.1007/s00134-016-4403-7
Pubmed ID
Authors

Elias Baedorf Kassis, Stephen H. Loring, Daniel Talmor

Abstract

The driving pressure of the respiratory system has been shown to strongly correlate with mortality in a recent large retrospective ARDSnet study. Respiratory system driving pressure [plateau pressure-positive end-expiratory pressure (PEEP)] does not account for variable chest wall compliance. Esophageal manometry can be utilized to determine transpulmonary driving pressure. We have examined the relationships between respiratory system and transpulmonary driving pressure, pulmonary mechanics and 28-day mortality. Fifty-six patients from a previous study were analyzed to compare PEEP titration to maintain positive transpulmonary end-expiratory pressure to a control protocol. Respiratory system and transpulmonary driving pressures and pulmonary mechanics were examined at baseline, 5 min and 24 h. Analysis of variance and linear regression were used to compare 28 day survivors versus non-survivors and the intervention group versus the control group, respectively. At baseline and 5 min there was no difference in respiratory system or transpulmonary driving pressure. By 24 h, survivors had lower respiratory system and transpulmonary driving pressures. Similarly, by 24 h the intervention group had lower transpulmonary driving pressure. This decrease was explained by improved elastance and increased PEEP. The results suggest that utilizing PEEP titration to target positive transpulmonary pressure via esophageal manometry causes both improved elastance and driving pressures. Treatment strategies leading to decreased respiratory system and transpulmonary driving pressure at 24 h may be associated with improved 28 day mortality. Studies to clarify the role of respiratory system and transpulmonary driving pressures as a prognosticator and bedside ventilator target are warranted.

X Demographics

X Demographics

The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 216 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 <1%
Portugal 1 <1%
Canada 1 <1%
Unknown 213 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 35 16%
Other 30 14%
Professor > Associate Professor 21 10%
Student > Doctoral Student 21 10%
Student > Master 17 8%
Other 48 22%
Unknown 44 20%
Readers by discipline Count As %
Medicine and Dentistry 141 65%
Nursing and Health Professions 13 6%
Engineering 6 3%
Agricultural and Biological Sciences 2 <1%
Biochemistry, Genetics and Molecular Biology 1 <1%
Other 8 4%
Unknown 45 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2022.
All research outputs
#2,779,033
of 23,539,593 outputs
Outputs from Intensive Care Medicine
#1,821
of 5,095 outputs
Outputs of similar age
#50,937
of 355,705 outputs
Outputs of similar age from Intensive Care Medicine
#9
of 44 outputs
Altmetric has tracked 23,539,593 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,095 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.2. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 355,705 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.