RT @__ice9: Even corticosteroids likely have a useful role in reducing pulmonary secretion of IL-1β during e.g. mechanical ventilation. ht…
Even corticosteroids likely have a useful role in reducing pulmonary secretion of IL-1β during e.g. mechanical ventilation. https://t.co/LWmAMV7ij1 https://t.co/b6sNdMYQ7C https://t.co/6FK77lAdJC https://t.co/Dj8QLFnzeH
@farid__jalali As noted in the other thread, I also suspect suppressing IL-1β associated with mechanical ventilation is likely relevant to the effect of corticosteroids in reducing mortality in severe COVID-19. https://t.co/zUsMzbQkrp
@EMostaque @farid__jalali @houndcl I think the fact that ventilated patients specifically showed treatment benefit from dexamethasone in RECOVERY is likely material. https://t.co/zUsMzbQkrp Mechanical ventilation can greatly increase IL-1β levels in part
@houndcl IL-1β is noted to be elevated in connection with ventilator-associated lung injury: https://t.co/BtJvjYRCIS https://t.co/ebyslLx9Nx https://t.co/ICTBjMnh6r And in ventilator-associated pneumonia: https://t.co/GiTFlrwzcN