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Targeted Delivery of VEGF after a Myocardial Infarction Reduces Collagen Deposition and Improves Cardiac Function

Overview of attention for article published in Cardiovascular Engineering and Technology, March 2012
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Title
Targeted Delivery of VEGF after a Myocardial Infarction Reduces Collagen Deposition and Improves Cardiac Function
Published in
Cardiovascular Engineering and Technology, March 2012
DOI 10.1007/s13239-012-0089-3
Pubmed ID
Authors

Jenna M. Rosano, Rabee Cheheltani, Bin Wang, Hardik Vora, Mohammad F. Kiani, Deborah L. Crabbe

Abstract

The development of adjunctive therapies which attenuate adverse remodeling and improve LV function post myocardial infarction (MI) is of significant clinical interest. Previously, we have shown that targeted delivery of therapeutic vascular endothelial growth factor (VEGF) to the infarct border zone significantly increases vascular perfusion and results in improvements in LV function. In this study, we tested the hypothesis that improvements in cardiac function observed with this novel targeted drug delivery system strongly correlate with reductions in collagen deposition in the scar tissue after an MI. Rats received anti-P-selectin conjugated immunoliposomes containing VEGF immediately post-MI. Over 4 weeks, evolutionary changes in LV geometry and function were correlated with collagen deposition and infarct size quantified by Gomori's trichrome and picrosirius red staining. Targeted VEGF treated hearts showed a 37% decrease in collagen deposition in the anterior wall, as well as significant improvements in LV filling pressures. Multi-regression analysis showed that the extent of collagen deposition post MI can be predicted by a linear combination of normalized LV mass and ejection fraction. Targeted delivery of VEGF post-MI results in significant decreases in collagen deposition and adverse remodeling. Improvements in cardiac function in this model are related to degree of collagen deposition and extent of scar formation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 31%
Student > Bachelor 5 19%
Student > Master 5 19%
Researcher 4 15%
Unspecified 2 8%
Other 2 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 23%
Medicine and Dentistry 6 23%
Engineering 5 19%
Biochemistry, Genetics and Molecular Biology 3 12%
Unspecified 2 8%
Other 4 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2016.
All research outputs
#10,063,226
of 12,579,850 outputs
Outputs from Cardiovascular Engineering and Technology
#59
of 74 outputs
Outputs of similar age
#85,258
of 120,118 outputs
Outputs of similar age from Cardiovascular Engineering and Technology
#2
of 2 outputs
Altmetric has tracked 12,579,850 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 74 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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