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Carbohydrate-based cancer vaccines: target cancer with sugar bullets

Overview of attention for article published in Glycoconjugate Journal, June 2012
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1 tweeter

Citations

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34 Dimensions

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43 Mendeley
Title
Carbohydrate-based cancer vaccines: target cancer with sugar bullets
Published in
Glycoconjugate Journal, June 2012
DOI 10.1007/s10719-012-9399-9
Pubmed ID
Authors

Chang-Cheng Liu, Xin-Shan Ye

Abstract

With the booming development of glycobiology and glycochemistry, more and more structures of tumor-associated carbohydrate antigens (TACAs) are identified. Their broad expression and high specificity in cancer make them important targets to develop cancer vaccines or immunotherapies. However, most of the TACAs are T cell-independent antigens, they cannot elicit a powerful enough immune response to prevent or treat cancer. Immunotolerance and immunosuppression are more easily induced due to their endogenous properties and the declining immunity of the patients. This review summarizes the recent efforts to overcome these obstacles: coupling the carbohydrate antigens to proper carriers such as proteins or some small molecule carriers, and chemically modifying the structures of the TACAs to enhance the immunogenicity of TACAs and break the immunotolerance.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 2%
United States 1 2%
Unknown 41 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 23%
Professor > Associate Professor 7 16%
Researcher 5 12%
Student > Bachelor 5 12%
Student > Master 5 12%
Other 11 26%
Readers by discipline Count As %
Chemistry 22 51%
Agricultural and Biological Sciences 10 23%
Biochemistry, Genetics and Molecular Biology 4 9%
Unspecified 3 7%
Chemical Engineering 2 5%
Other 2 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2012.
All research outputs
#2,748,735
of 3,627,074 outputs
Outputs from Glycoconjugate Journal
#76
of 109 outputs
Outputs of similar age
#47,778
of 71,901 outputs
Outputs of similar age from Glycoconjugate Journal
#4
of 9 outputs
Altmetric has tracked 3,627,074 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 109 research outputs from this source. They receive a mean Attention Score of 1.9. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 71,901 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.