| Title |
Generation of 3D human gastrointestinal organoids: principle and applications
|
|---|---|
| Published in |
Cell Regeneration, June 2020
|
| DOI | 10.1186/s13619-020-00040-w |
| Pubmed ID | |
| Authors |
Mengxian Zhang, Yuan Liu, Ye-Guang Chen |
| Abstract |
The stomach and intestine are important organs for food digestion, nutrient absorption, immune protection and hormone production. Gastrointestinal diseases such as cancer and ulcer are big threats to human health. Appropriate disease models are in sore need for mechanistic understanding and drug discovery. Organoids are three-dimensional in vitro cultured structures derived from tissues and pluripotent stem cells with multiple types of cells and mimicking in vivo tissues in major aspects. They have a great potential in regenerative medicine and personalized medicine. Here, we review the major signaling pathways regulating gastrointestinal epithelial homeostasis, summarize different methods to generate human gastrointestinal organoids and highlight their applications in biological research and medical practice. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 16% |
| Student > Bachelor | 8 | 13% |
| Researcher | 7 | 11% |
| Student > Ph. D. Student | 5 | 8% |
| Student > Doctoral Student | 4 | 6% |
| Other | 14 | 23% |
| Unknown | 14 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 17 | 27% |
| Medicine and Dentistry | 8 | 13% |
| Agricultural and Biological Sciences | 4 | 6% |
| Chemistry | 2 | 3% |
| Engineering | 2 | 3% |
| Other | 9 | 15% |
| Unknown | 20 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2022.
All research outputs
#13,936,629
of 22,792,160 outputs
Outputs from Cell Regeneration
#55
of 150 outputs
Outputs of similar age
#212,914
of 397,681 outputs
Outputs of similar age from Cell Regeneration
#3
of 10 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 150 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 59% of its peers.
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We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.