Title |
Increased oxygen consumption and OXPHOS potential in superhealer mesenchymal stem cells
|
---|---|
Published in |
Cell Regeneration, June 2012
|
DOI | 10.1186/2045-9769-1-3 |
Pubmed ID | |
Authors |
Curtis C Hughey, Maria P Alfaro, Darrell D Belke, Jeffery N Rottman, Pampee P Young, David H Wasserman, Jane Shearer |
Abstract |
Cell-based therapies show promise in repairing cardiac tissue and improving contractile performance following a myocardial infarction. Despite this, ischemia-induced death of transplanted cells remains a major hurdle to the efficacy of treatment. 'Superhealer' MRL/MpJ mesenchymal stem cells (MRL-MSCs) have been reported to exhibit increased engraftment resulting in reduced infarct size and enhanced contractile function. This study determines whether intrinsic differences in mitochondrial oxidative phosphorylation (OXPHOS) assist in explaining the enhanced cellular survival and engraftment of MRL-MSCs. |
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