| Title |
Erythropoietin (EPO) in acute kidney injury
|
|---|---|
| Published in |
Annals of Intensive Care, March 2011
|
| DOI | 10.1186/2110-5820-1-3 |
| Pubmed ID | |
| Authors |
Elizabeth Moore, Rinaldo Bellomo |
| Abstract |
Erythropoietin (EPO) is a 30.4 kDa glycoprotein produced by the kidney, and is mostly well-known for its physiological function in regulating red blood cell production in the bone marrow. Accumulating evidence, however, suggests that EPO has additional organ protective effects, which may be useful in the prevention or treatment of acute kidney injury. These protective mechanisms are multifactorial in nature and include inhibition of apoptotic cell death, stimulation of cellular regeneration, inhibition of deleterious pathways, and promotion of recovery.In this article, we review the physiology of EPO, assess previous work that supports the role of EPO as a general tissue protective agent, and explain the mechanisms by which it may achieve this tissue protective effect. We then focus on experimental and clinical data that suggest that EPO has a kidney protective effect. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| France | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 108 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 16% |
| Student > Bachelor | 15 | 14% |
| Researcher | 14 | 13% |
| Student > Ph. D. Student | 14 | 13% |
| Other | 10 | 9% |
| Other | 21 | 19% |
| Unknown | 19 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 43 | 39% |
| Agricultural and Biological Sciences | 21 | 19% |
| Biochemistry, Genetics and Molecular Biology | 8 | 7% |
| Neuroscience | 4 | 4% |
| Nursing and Health Professions | 3 | 3% |
| Other | 12 | 11% |
| Unknown | 20 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2012.
All research outputs
#17,659,617
of 22,668,244 outputs
Outputs from Annals of Intensive Care
#871
of 1,033 outputs
Outputs of similar age
#94,180
of 108,409 outputs
Outputs of similar age from Annals of Intensive Care
#8
of 9 outputs
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