| Title |
Usefulness of presepsin in the diagnosis of sepsis in a multicenter prospective study
|
|---|---|
| Published in |
Journal of Infection & Chemotherapy, June 2012
|
| DOI | 10.1007/s10156-012-0435-2 |
| Pubmed ID | |
| Authors |
Shigeatsu Endo, Yasushi Suzuki, Gaku Takahashi, Tatsuyori Shozushima, Hiroyasu Ishikura, Akira Murai, Takeshi Nishida, Yuhei Irie, Masanao Miura, Hironobu Iguchi, Yasuo Fukui, Kimiaki Tanaka, Tsuyoshi Nojima, Yoshikazu Okamura |
| Abstract |
The clinical usefulness of presepsin for discriminating between bacterial and nonbacterial infections (including systemic inflammatory response syndrome) was studied and compared with procalcitonin (PCT) and interleukin-6 (IL-6) in a multicenter prospective study. Suspected sepsis patients (n = 207) were enrolled into the study. Presepsin levels in patients with systemic bacterial infection and localized bacterial infection were significantly higher than in those with nonbacterial infections. In addition, presepsin, PCT, and IL-6 levels in patients with bacterial infectious disease were significantly higher than in those with nonbacterial infectious disease (P < 0.0001, P < 0.0001, and P < 0.0001, respectively). The area under the receiver operating characteristic curve was 0.908 for presepsin, 0.905 for PCT, and 0.825 for IL-6 in patients with bacterial infectious disease and those with nonbacterial infectious disease. The cutoff value of presepsin for discrimination of bacterial and nonbacterial infectious diseases was determined to be 600 pg/ml, of which the clinical sensitivity and specificity were 87.8 % and 81.4 %, respectively. Presepsin levels did not differ significantly between patients with gram-positive and gram-negative bacterial infections. The sensitivity of blood culture was 35.4 %; that for presepsin was 91.9 %. Also there were no significant differences in presepsin levels between the blood culture-positive and -negative groups. Consequently, presepsin is useful for the diagnosis of sepsis, and it is superior to conventional markers and blood culture. |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | <1% |
| Germany | 1 | <1% |
| Egypt | 1 | <1% |
| Romania | 1 | <1% |
| Croatia | 1 | <1% |
| Unknown | 143 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 11% |
| Student > Ph. D. Student | 15 | 10% |
| Student > Bachelor | 15 | 10% |
| Other | 12 | 8% |
| Student > Postgraduate | 10 | 7% |
| Other | 35 | 24% |
| Unknown | 45 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 76 | 51% |
| Agricultural and Biological Sciences | 6 | 4% |
| Immunology and Microbiology | 5 | 3% |
| Biochemistry, Genetics and Molecular Biology | 5 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 1% |
| Other | 8 | 5% |
| Unknown | 46 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2018.
All research outputs
#5,338,695
of 25,373,627 outputs
Outputs from Journal of Infection & Chemotherapy
#188
of 1,595 outputs
Outputs of similar age
#35,417
of 181,067 outputs
Outputs of similar age from Journal of Infection & Chemotherapy
#2
of 12 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,595 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 181,067 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.