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Usefulness of presepsin in the diagnosis of sepsis in a multicenter prospective study

Overview of attention for article published in Journal of Infection & Chemotherapy, January 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#33 of 719)
  • High Attention Score compared to outputs of the same age (82nd percentile)

Mentioned by

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7 patents
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1 Facebook page

Citations

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124 Dimensions

Readers on

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71 Mendeley
Title
Usefulness of presepsin in the diagnosis of sepsis in a multicenter prospective study
Published in
Journal of Infection & Chemotherapy, January 2012
DOI 10.1007/s10156-012-0435-2
Pubmed ID
Authors

Shigeatsu Endo, Yasushi Suzuki, Gaku Takahashi, Tatsuyori Shozushima, Hiroyasu Ishikura, Akira Murai, Takeshi Nishida, Yuhei Irie, Masanao Miura, Hironobu Iguchi, Yasuo Fukui, Kimiaki Tanaka, Tsuyoshi Nojima, Yoshikazu Okamura

Abstract

The clinical usefulness of presepsin for discriminating between bacterial and nonbacterial infections (including systemic inflammatory response syndrome) was studied and compared with procalcitonin (PCT) and interleukin-6 (IL-6) in a multicenter prospective study. Suspected sepsis patients (n = 207) were enrolled into the study. Presepsin levels in patients with systemic bacterial infection and localized bacterial infection were significantly higher than in those with nonbacterial infections. In addition, presepsin, PCT, and IL-6 levels in patients with bacterial infectious disease were significantly higher than in those with nonbacterial infectious disease (P < 0.0001, P < 0.0001, and P < 0.0001, respectively). The area under the receiver operating characteristic curve was 0.908 for presepsin, 0.905 for PCT, and 0.825 for IL-6 in patients with bacterial infectious disease and those with nonbacterial infectious disease. The cutoff value of presepsin for discrimination of bacterial and nonbacterial infectious diseases was determined to be 600 pg/ml, of which the clinical sensitivity and specificity were 87.8 % and 81.4 %, respectively. Presepsin levels did not differ significantly between patients with gram-positive and gram-negative bacterial infections. The sensitivity of blood culture was 35.4 %; that for presepsin was 91.9 %. Also there were no significant differences in presepsin levels between the blood culture-positive and -negative groups. Consequently, presepsin is useful for the diagnosis of sepsis, and it is superior to conventional markers and blood culture.

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Croatia 1 1%
Germany 1 1%
Egypt 1 1%
Hungary 1 1%
Romania 1 1%
Unknown 66 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 15%
Researcher 9 13%
Student > Bachelor 9 13%
Student > Postgraduate 8 11%
Unspecified 7 10%
Other 27 38%
Readers by discipline Count As %
Medicine and Dentistry 48 68%
Unspecified 8 11%
Agricultural and Biological Sciences 6 8%
Biochemistry, Genetics and Molecular Biology 2 3%
Immunology and Microbiology 2 3%
Other 5 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2018.
All research outputs
#2,146,269
of 12,519,038 outputs
Outputs from Journal of Infection & Chemotherapy
#33
of 719 outputs
Outputs of similar age
#20,202
of 118,606 outputs
Outputs of similar age from Journal of Infection & Chemotherapy
#1
of 1 outputs
Altmetric has tracked 12,519,038 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 719 research outputs from this source. They receive a mean Attention Score of 1.9. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 118,606 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them