RT @gerardosolisp: En conclusión: El mecanismo de daño es: Infusión de propofol dosis altas = bloqueo de FFA mitocondriales = ⬇️ cadena de…
En conclusión: El mecanismo de daño es: Infusión de propofol dosis altas = bloqueo de FFA mitocondriales = ⬇️ cadena de transporte de electrones = ⬇️producción ATP = muerte musculo cardiaco. Recordar: Px crítico es vulnerable https://t.co/B1zGiDHwdL htt
Los FFA de cadena larga requieren conjugación para cruzar la mitocondria y sufrir oxidación; los FFA de cadena corta no. Por tanto: el propofol puede inhibir tanto la conjugación como la oxidación de FFA, bloqueando la utilización de FFA para producir ATP.
RT @AvrahamCooperMD: 14/ At the same time, there are many other metabolic demands and stressors on muscle during critical illness. PRIS re…
RT @AvrahamCooperMD: 12/ Recall from tweet #8 that PRIS associates w/ ⬆️ short and long-chain FFAs in the serum. This suggests that prop…
RT @AvrahamCooperMD: 11/ Short-chain FFAs, on the other hand, can cross the mitochondrial membrane without conjugation. Instead they go s…
RT @AvrahamCooperMD: 11/ Short-chain FFAs, on the other hand, can cross the mitochondrial membrane without conjugation. Instead they go s…
RT @AvrahamCooperMD: 12/ Recall from tweet #8 that PRIS associates w/ ⬆️ short and long-chain FFAs in the serum. This suggests that prop…
RT @AvrahamCooperMD: 14/ At the same time, there are many other metabolic demands and stressors on muscle during critical illness. PRIS re…
RT @AvrahamCooperMD: 12/ Recall from tweet #8 that PRIS associates w/ ⬆️ short and long-chain FFAs in the serum. This suggests that prop…
RT @AvrahamCooperMD: 11/ Short-chain FFAs, on the other hand, can cross the mitochondrial membrane without conjugation. Instead they go s…
RT @AvrahamCooperMD: 12/ Recall from tweet #8 that PRIS associates w/ ⬆️ short and long-chain FFAs in the serum. This suggests that prop…
RT @AvrahamCooperMD: 14/ At the same time, there are many other metabolic demands and stressors on muscle during critical illness. PRIS re…
RT @AvrahamCooperMD: 12/ Recall from tweet #8 that PRIS associates w/ ⬆️ short and long-chain FFAs in the serum. This suggests that prop…
RT @AvrahamCooperMD: 12/ Recall from tweet #8 that PRIS associates w/ ⬆️ short and long-chain FFAs in the serum. This suggests that prop…
RT @AvrahamCooperMD: 12/ Recall from tweet #8 that PRIS associates w/ ⬆️ short and long-chain FFAs in the serum. This suggests that prop…
RT @AvrahamCooperMD: 12/ Recall from tweet #8 that PRIS associates w/ ⬆️ short and long-chain FFAs in the serum. This suggests that prop…
14/ At the same time, there are many other metabolic demands and stressors on muscle during critical illness. PRIS reflects a mismatch between this demand and available energy supply, which culminates in muscle necrosis. https://t.co/fCkdilgRJt https://
12/ Recall from tweet #8 that PRIS associates w/ ⬆️ short and long-chain FFAs in the serum. This suggests that propofol can inhibit both FFA conjugation and oxidation, blocking short and long chain FFA utilization for ATP production. https://t.co/fCkdi
11/ Short-chain FFAs, on the other hand, can cross the mitochondrial membrane without conjugation. Instead they go straight into oxidation and conversion to acetyl-CoA, prior to being used for ATP production (see step 2 in the figure). https://t.co/fCk