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Rapid Absorption of Dry-Powder Intranasal Oxytocin

Overview of attention for article published in Pharmaceutical Research, May 2016
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2 tweeters

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15 Mendeley
Title
Rapid Absorption of Dry-Powder Intranasal Oxytocin
Published in
Pharmaceutical Research, May 2016
DOI 10.1007/s11095-016-1929-x
Pubmed ID
Authors

Mikolaj Milewski, Adrian Goodey, Dinah Lee, Eric Rimmer, Robert Saklatvala, Shuzo Koyama, Mic Iwashima, Shunji Haruta

Abstract

To probe the suitability of a dry-powder oxytocin formulation containing a carrier (μco™; SNBL, Ltd.) for intranasal (IN) administration to treat post-partum hemorrhage in the developing world. Specifically, to investigate (1) whether IN administration can achieve rapid systemic absorption in cynomolgus monkeys, and (2) whether the formulation exhibits sufficient physical and chemical stability. This study was conducted to support Merck for Mothers, Merck's 10-year global initiative to end preventable maternal deaths. A partial-crossover pharmacokinetic (PK) study in cynomolgus monkeys (n = 6) was utilized to compare in vivo absorption of dry-powder IN oxytocin at three dose levels against an IM injection of an aqueous oxytocin formulation. Particle size distribution, delivered dose and chemical assay were monitored over a 12 month stability study. IN administration of oxytocin resulted in short (5 min) Tmax and good dose linearity in AUC and Cmax over the dose range tested (10-80 IU per animal). The relative bioavailability (BA) of IN oxytocin to IM injection was approximately 12%. The 80 IU formulation exhibited good physical stability and consistent dosing. After 12 months at 30°C/65%RH, pouched samples retained 86.0% of their original assay value. The PK and stability data suggests that IN administration of oxytocin formulated in the μco™ carrier may represent a viable option for rapid systemic absorption in humans and a product compatible with resource-scarce regions.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Austria 1 7%
Unknown 14 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 27%
Researcher 3 20%
Student > Postgraduate 2 13%
Other 2 13%
Student > Ph. D. Student 2 13%
Other 2 13%
Readers by discipline Count As %
Medicine and Dentistry 5 33%
Pharmacology, Toxicology and Pharmaceutical Science 3 20%
Psychology 2 13%
Agricultural and Biological Sciences 2 13%
Social Sciences 1 7%
Other 2 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2016.
All research outputs
#7,406,012
of 12,330,736 outputs
Outputs from Pharmaceutical Research
#1,498
of 1,966 outputs
Outputs of similar age
#138,708
of 275,025 outputs
Outputs of similar age from Pharmaceutical Research
#36
of 57 outputs
Altmetric has tracked 12,330,736 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,966 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,025 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.