Title |
The absorption of orally supplied β-alanine and its effect on muscle carnosine synthesis in human vastus lateralis
|
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Published in |
Amino Acids, March 2006
|
DOI | 10.1007/s00726-006-0299-9 |
Pubmed ID | |
Authors |
R. C. Harris, M. J. Tallon, M. Dunnett, L. Boobis, J. Coakley, H. J. Kim, J. L. Fallowfield, C. A. Hill, C. Sale, J. A. Wise |
Abstract |
Beta-alanine in blood-plasma when administered as A) histidine dipeptides (equivalent to 40 mg . kg(-1) bwt of beta-alanine) in chicken broth, or B) 10, C) 20 and D) 40 mg . kg(-1) bwt beta-alanine (CarnoSyn, NAI, USA), peaked at 428 +/- SE 66, 47 +/- 13, 374 +/- 68 and 833 +/- 43 microM. Concentrations regained baseline at 2 h. Carnosine was not detected in plasma with A) although traces of this and anserine were found in urine. Loss of beta-alanine in urine with B) to D) was <5%. Plasma taurine was increased by beta-alanine ingestion but this did not result in any increased loss via urine. Pharmacodynamics were further investigated with 3 x B) per day given for 15 d. Dietary supplementation with I) 3.2 and II) 6.4 g . d(-1) beta-alanine (as multiple doses of 400 or 800 mg) or III) L-carnosine (isomolar to II) for 4 w resulted in significant increases in muscle carnosine estimated at 42.1, 64.2 and 65.8%. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 33% |
United Kingdom | 3 | 33% |
Unknown | 3 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 5 | 56% |
Practitioners (doctors, other healthcare professionals) | 3 | 33% |
Members of the public | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | <1% |
Germany | 1 | <1% |
Brazil | 1 | <1% |
Switzerland | 1 | <1% |
New Zealand | 1 | <1% |
Poland | 1 | <1% |
Unknown | 440 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 92 | 21% |
Student > Bachelor | 77 | 17% |
Student > Ph. D. Student | 41 | 9% |
Researcher | 29 | 6% |
Student > Postgraduate | 24 | 5% |
Other | 64 | 14% |
Unknown | 120 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Sports and Recreations | 118 | 26% |
Agricultural and Biological Sciences | 59 | 13% |
Medicine and Dentistry | 45 | 10% |
Nursing and Health Professions | 30 | 7% |
Biochemistry, Genetics and Molecular Biology | 17 | 4% |
Other | 48 | 11% |
Unknown | 130 | 29% |