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Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes

Overview of attention for article published in Diabetologia, May 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

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6 news outlets
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1 tweeter

Citations

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14 Mendeley
Title
Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes
Published in
Diabetologia, May 2016
DOI 10.1007/s00125-016-3973-9
Pubmed ID
Authors

Rashmi B. Prasad, Anna Lessmark, Peter Almgren, Györgyi Kovacs, Ola Hansson, Nikolay Oskolkov, Marta Vitai, Claes Ladenvall, Peter Kovacs, Joao Fadista, Michael Lachmann, Yuedan Zhou, Emily Sonestedt, Wenny Poon, Claes B. Wollheim, Marju Orho-Melander, Michael Stumvoll, Tiinamaija Tuomi, Svante Pääbo, Laszlo Koranyi, Leif Groop

Abstract

Genome-wide association studies (GWAS) have identified more than 65 genetic loci associated with risk of type 2 diabetes. However, the contribution of distorted parental transmission of alleles to risk of type 2 diabetes has been mostly unexplored. Our goal was therefore to search for parent-of-origin effects (POE) among type 2 diabetes loci in families. Families from the Botnia study (n = 4,211, 1,083 families) were genotyped for 72 single-nucleotide polymorphisms (SNPs) associated with type 2 diabetes and assessed for POE on type 2 diabetes. The family-based Hungarian Transdanubian Biobank (HTB) (n = 1,463, >135 families) was used to replicate SNPs showing POE. Association of type 2 diabetes loci within families was also tested. Three loci showed nominal POE, including the previously reported variants in KCNQ1, for type 2 diabetes in families from Botnia (rs2237895: p POE  = 0.037), which can be considered positive controls. The strongest POE was seen for rs7578597 SNP in the THADA gene, showing excess transmission of the maternal risk allele T to diabetic offspring (Botnia: p POE  = 0.01; HTB p POE  = 0.045). These data are consistent with previous evidence of allelic imbalance for expression in islets, suggesting that the THADA gene can be imprinted in a POE-specific fashion. Five CpG sites, including those flanking rs7578597, showed differential methylation between diabetic and non-diabetic donor islets. Taken together, the data emphasise the need for genetic studies to consider from which parent an offspring has inherited a susceptibility allele.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 7%
Unknown 13 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 21%
Student > Master 3 21%
Researcher 2 14%
Librarian 2 14%
Student > Postgraduate 1 7%
Other 3 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 36%
Medicine and Dentistry 5 36%
Agricultural and Biological Sciences 3 21%
Social Sciences 1 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 46. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2016.
All research outputs
#307,126
of 12,225,951 outputs
Outputs from Diabetologia
#220
of 3,621 outputs
Outputs of similar age
#12,714
of 277,267 outputs
Outputs of similar age from Diabetologia
#15
of 135 outputs
Altmetric has tracked 12,225,951 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,621 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.1. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,267 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 135 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.