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Epigenetic changes in leukocytes after 8 weeks of resistance exercise training

Overview of attention for article published in European Journal of Applied Physiology and Occupational Physiology, May 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

Mentioned by

twitter
9 tweeters

Citations

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12 Dimensions

Readers on

mendeley
75 Mendeley
Title
Epigenetic changes in leukocytes after 8 weeks of resistance exercise training
Published in
European Journal of Applied Physiology and Occupational Physiology, May 2016
DOI 10.1007/s00421-016-3382-2
Pubmed ID
Authors

Joshua Denham, Francine Z. Marques, Emma L. Bruns, Brendan J. O’Brien, Fadi J. Charchar

Abstract

Regular engagement in resistance exercise training elicits many health benefits including improvement to muscular strength, hypertrophy and insulin sensitivity, though the underpinning molecular mechanisms are poorly understood. The purpose of this study was to determine the influence 8 weeks of resistance exercise training has on leukocyte genome-wide DNA methylation and gene expression in healthy young men. Eight young (21.1 ± 2.2 years) men completed one repetition maximum (1RM) testing before completing 8 weeks of supervised, thrice-weekly resistance exercise training comprising three sets of 8-12 repetitions with a load equivalent to 80 % of 1RM. Blood samples were collected at rest before and after the 8-week training intervention. Genome-wide DNA methylation and gene expression were assessed on isolated leukocyte DNA and RNA using the 450K BeadChip and HumanHT-12 v4 Expression BeadChip (Illumina), respectively. Resistance exercise training significantly improved upper and lower body strength concurrently with diverse genome-wide DNA methylation and gene expression changes (p ≤ 0. 01). DNA methylation changes occurred at multiple regions throughout the genome in context with genes and CpG islands, and in genes relating to axon guidance, diabetes and immune pathways. There were multiple genes with increased expression that were enriched for RNA processing and developmental proteins. Growth factor genes-GHRH and FGF1-showed differential methylation and mRNA expression changes after resistance training. Our findings indicate that resistance exercise training improves muscular strength and is associated with reprogramming of the leukocyte DNA methylome and transcriptome.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sweden 1 1%
Brazil 1 1%
Unknown 73 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 23%
Student > Ph. D. Student 14 19%
Researcher 8 11%
Student > Bachelor 5 7%
Professor > Associate Professor 5 7%
Other 18 24%
Unknown 8 11%
Readers by discipline Count As %
Sports and Recreations 13 17%
Medicine and Dentistry 12 16%
Agricultural and Biological Sciences 11 15%
Biochemistry, Genetics and Molecular Biology 11 15%
Nursing and Health Professions 5 7%
Other 8 11%
Unknown 15 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2017.
All research outputs
#3,062,876
of 12,382,688 outputs
Outputs from European Journal of Applied Physiology and Occupational Physiology
#993
of 2,796 outputs
Outputs of similar age
#73,699
of 268,729 outputs
Outputs of similar age from European Journal of Applied Physiology and Occupational Physiology
#22
of 48 outputs
Altmetric has tracked 12,382,688 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,796 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.1. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,729 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.