@MuinJKhoury @McVeighTerri @JAMA_current Really important point, made in a different way by Les Biesecker here: https://t.co/bhH0VUbErz Ultimately a test is used to help a clinician to make a diagnosis based on all available evidence. It’s ultimately the
RT @GenomeDiver: Fascinating and challenging perspective from @GenomicsLGB. The genomic testing lab helps, but the clinician ultimately ma…
RT @GenomeDiver: Fascinating and challenging perspective from @GenomicsLGB. The genomic testing lab helps, but the clinician ultimately ma…
Fascinating and challenging perspective from @GenomicsLGB. The genomic testing lab helps, but the clinician ultimately makes the genetic diagnosis. Genomic screening and genomic diagnostic testing—two very different kettles of fish https://t.co/y2liPamb4
Genomic screening and genomic diagnostic testing—two very different kettles of fish - https://t.co/xSLS0pUuLh
RT @m_disrupt: Genomic Screening and Genomic Testing are not the same thing. Learn why. https://t.co/5VpmV7eH5b
RT @John_H_McD: @HastingsJ123 Absolutely. I'm certainly not advocating for people to go out and do this. Huge challenges; 1. Can we trust…
RT @John_H_McD: @HastingsJ123 Absolutely. I'm certainly not advocating for people to go out and do this. Huge challenges; 1. Can we trust…
@HastingsJ123 Absolutely. I'm certainly not advocating for people to go out and do this. Huge challenges; 1. Can we trust the data? 2. Can we trust the interpretation of that data? 3. Would I have ordered that test in the first place? This article address
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @m_disrupt: Genomic Screening and Genomic Testing are not the same thing. Learn why. https://t.co/5VpmV7eH5b
Genomic Screening and Genomic Testing are not the same thing. Learn why. https://t.co/5VpmV7eH5b
RT @pash22: Genomic screening and genomic diagnostic testing: two very different kettles of fish https://t.co/hIg6uCB2D3 via @GenomicsLGB
RT @pash22: Genomic screening and genomic diagnostic testing: two very different kettles of fish https://t.co/hIg6uCB2D3 via @GenomicsLGB
Genomic screening and genomic diagnostic testing: two very different kettles of fish https://t.co/hIg6uCB2D3 via @GenomicsLGB
"Genomic test results for patients in diagnostic and screening contexts. The clinical context in which the testing was done is a major determinant of the diagnosis of the patient." https://t.co/piSguvkWfb
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
@aifbw @trishgreenhalgh @MattHancock Would you trust the current government with sensitive genetic information from your family? And, as I’m sure you know, there is a world of difference between testing and screening, well expressed here: https://t.co/cZL9
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @leilaluheshi: Required reading for anyone who has an interest in getting genomic medicine ‘right’ on impact of WGS used in screening vs…
Too many long words in it for Hancock!
See.....Bayes really is important!
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
Prior probability matters https://t.co/AsI75fd3VT
RT @leilaluheshi: Required reading for anyone who has an interest in getting genomic medicine ‘right’ on impact of WGS used in screening vs…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @leilaluheshi: Required reading for anyone who has an interest in getting genomic medicine ‘right’ on impact of WGS used in screening vs…
RT @OphirKlein: Great explanation of difference between genomic screening and testing by Les Biesecker @GenomicsLGB https://t.co/FHt6XO5C…
RT @OphirKlein: Great explanation of difference between genomic screening and testing by Les Biesecker @GenomicsLGB https://t.co/FHt6XO5C…
RT @OphirKlein: Great explanation of difference between genomic screening and testing by Les Biesecker @GenomicsLGB https://t.co/FHt6XO5C…
Great explanation of difference between genomic screening and testing by Les Biesecker @GenomicsLGB https://t.co/FHt6XO5Cnn
RT @leilaluheshi: Required reading for anyone who has an interest in getting genomic medicine ‘right’ on impact of WGS used in screening vs…
RT @MarcelDinger: Beautiful explanation from Les Biesecker of the significance of #phenotype in enabling sensible clinical reporting from g…
RT @MarcelDinger: Beautiful explanation from Les Biesecker of the significance of #phenotype in enabling sensible clinical reporting from g…
In the end, #genomic testing is more similar to, than it is different from, a hematocrit or serum sodium test result. All three tests are extremely useful if interpreted correctly, given the clinical context in which they are used. #ngs #screening https://
A nice weekend read
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MarcelDinger: Beautiful explanation from Les Biesecker of the significance of #phenotype in enabling sensible clinical reporting from g…
RT @SerefArikan: Bayes theorem applies to everything everyone does :) https://t.co/9UN18vIUj2
Bayes theorem applies to everything everyone does :)
RT @MarcelDinger: Beautiful explanation from Les Biesecker of the significance of #phenotype in enabling sensible clinical reporting from g…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @leilaluheshi: Required reading for anyone who has an interest in getting genomic medicine ‘right’ on impact of WGS used in screening vs…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @generoom: Anyone ordering a #genomic #diagnostic test should read this. Genomic tests are not deterministic, and must always be interpr…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @leilaluheshi: Required reading for anyone who has an interest in getting genomic medicine ‘right’ on impact of WGS used in screening vs…
Many issues and nuances here, but one is the potentially misleading use of the term ‘false positive’. In screening, it’s about prediction of risk. That the patient doesn’t (yet) have symptoms doesn’t make it ‘false’. That’s the whole point of screening hea
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
Nice
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @HelenVFirth: Essential reading for all those involved in using genomic data in clinical practice! Les Biesecker explains the critical i…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @HelenVFirth: Essential reading for all those involved in using genomic data in clinical practice! Les Biesecker explains the critical i…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
A very valuable insight from Les Bieseker from @nhgri. However, the answer is not improved test ordering. Our inescapable future is screening. Instead, we have to have a way of allowing genetic test results to prompt targeted reverse phenotyping. https:
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @generoom: Anyone ordering a #genomic #diagnostic test should read this. Genomic tests are not deterministic, and must always be interpr…
RT @leilaluheshi: Required reading for anyone who has an interest in getting genomic medicine ‘right’ on impact of WGS used in screening vs…
Anyone ordering a #genomic #diagnostic test should read this. Genomic tests are not deterministic, and must always be interpreted in context.
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @leilaluheshi: Required reading for anyone who has an interest in getting genomic medicine ‘right’ on impact of WGS used in screening vs…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MarcelDinger: Beautiful explanation from Les Biesecker of the significance of #phenotype in enabling sensible clinical reporting from g…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @leilaluheshi: Required reading for anyone who has an interest in getting genomic medicine ‘right’ on impact of WGS used in screening vs…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
Bookmarking this interesting-looking article for later reading. Need to have a few coffees first!
“By contextualizing genomic test results, clinicians can better manage their patients in both diagnostic and screening contexts.”
Required reading for anyone who has an interest in getting genomic medicine ‘right’ on impact of WGS used in screening vs diagnosis. And consequences of false positives for patient and health services. One for my old colleagues at @PHGFoundation
RT @MarcelDinger: Beautiful explanation from Les Biesecker of the significance of #phenotype in enabling sensible clinical reporting from g…
RT @HelenVFirth: Essential reading for all those involved in using genomic data in clinical practice! Les Biesecker explains the critical i…
RT @HelenVFirth: Essential reading for all those involved in using genomic data in clinical practice! Les Biesecker explains the critical i…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MuinJKhoury: “Bayes theorem applies to everything clinicians do:” Les Biesecker writes in @GenomeMedicine about the simple but fundamen…
RT @MarcelDinger: Beautiful explanation from Les Biesecker of the significance of #phenotype in enabling sensible clinical reporting from g…