| Title |
Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects
|
|---|---|
| Published in |
EJNMMI Research, April 2012
|
| DOI | 10.1186/2191-219x-2-15 |
| Pubmed ID | |
| Authors |
Aurelija Jučaite, Zsolt Cselényi, Annie Arvidsson, Gabrielle Åhlberg, Per Julin, Katarina Varnäs, Per Stenkrona, Jan Andersson, Christer Halldin, Lars Farde |
| Abstract |
Positron-emission tomography and the radioligand [11C](R)-PK11195 have been used for the imaging of the translocator protein (TSPO) and applied to map microglia cells in the brain in neuropsychiatric disorders. [11C](R)-PK11195 binding has been quantified using reference region approaches, with the reference defined anatomically or using unsupervised or supervised clustering algorithms. Kinetic compartment modelling so far has not been presented. In the present test-retest study, we examine the characteristics of [11C](R)-PK11195 binding in detail, using the classical compartment analysis with a metabolite-corrected arterial input function. |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 3% |
| Italy | 1 | 1% |
| Netherlands | 1 | 1% |
| Spain | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 65 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 30% |
| Researcher | 16 | 23% |
| Student > Master | 6 | 8% |
| Student > Bachelor | 4 | 6% |
| Student > Postgraduate | 4 | 6% |
| Other | 6 | 8% |
| Unknown | 14 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 28% |
| Neuroscience | 14 | 20% |
| Physics and Astronomy | 6 | 8% |
| Psychology | 4 | 6% |
| Engineering | 3 | 4% |
| Other | 5 | 7% |
| Unknown | 19 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2012.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from EJNMMI Research
#442
of 612 outputs
Outputs of similar age
#159,413
of 175,210 outputs
Outputs of similar age from EJNMMI Research
#4
of 4 outputs
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