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Identification and Localization of Gold Nanoparticles in Potassium Ion Pores: Implications for Kir Blockade

Overview of attention for article published in Cardiology and Therapy, April 2016
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Title
Identification and Localization of Gold Nanoparticles in Potassium Ion Pores: Implications for Kir Blockade
Published in
Cardiology and Therapy, April 2016
DOI 10.1007/s40119-016-0060-8
Pubmed ID
Authors

Chur Chin, Yu Shin Park

Abstract

In our previous study, we found that negatively charged gold nanoparticles with spermidine have the potential of blocking inwardly rectifying potassium channels (Kir), both at the cellular and the tissue level. For the purpose of the present study, we purified the cytoplasmic domain of the Kir 3.1 receptor from Escherichia coli. Using single particles with surface coating by transmission electron microscopy, we identified the gold nanoparticles at the cytoplasmic side of the human Kir channel. Energy-dispersive X-ray spectroscopy showed the presence of the gold deposits in the cytoplasmic domain of the Kir receptor. In conclusion, we could identify undecagold in the ion pore of the Kir3.1 channel in order to clarify its direct blocking effect in the Kir ion pore by undecagold.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 25%
Student > Master 1 25%
Student > Postgraduate 1 25%
Unspecified 1 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 50%
Unspecified 1 25%
Medicine and Dentistry 1 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2016.
All research outputs
#10,033,227
of 12,539,922 outputs
Outputs from Cardiology and Therapy
#73
of 111 outputs
Outputs of similar age
#182,758
of 262,255 outputs
Outputs of similar age from Cardiology and Therapy
#4
of 8 outputs
Altmetric has tracked 12,539,922 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 111 research outputs from this source. They receive a mean Attention Score of 1.7. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,255 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.