Technical advance in targeted NGS analysis enables identification of lung cancer risk-associated low frequency TP53, PIK3CA, and BRAF mutations in airway epithelial cells

Measurement of variants in the 0.05–1.0% VAF range will aid analysis of AEC mutations associated with cancer risk. TP53 mutations were more prevalent and enriched for tobacco smoke and age signatures compared to matched non-cancer subjects. https://t.co/P