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Polymorphisms in DNA repair and oxidative stress genes associated with pre-treatment cognitive function in breast cancer survivors: an exploratory study

Overview of attention for article published in SpringerPlus, April 2016
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Title
Polymorphisms in DNA repair and oxidative stress genes associated with pre-treatment cognitive function in breast cancer survivors: an exploratory study
Published in
SpringerPlus, April 2016
DOI 10.1186/s40064-016-2061-4
Pubmed ID
Authors

Theresa A. Koleck, Catherine M. Bender, Susan M. Sereika, Adam M. Brufsky, Barry C. Lembersky, Priscilla F. McAuliffe, Shannon L. Puhalla, Priya Rastogi, Yvette P. Conley

Abstract

The purpose of this exploratory candidate gene association study was to examine relationships between polymorphisms in oxidative stress and DNA repair genes and pre-adjuvant therapy cognitive function (CF) in postmenopausal women diagnosed with early stage-breast cancer. Using a neuropsychological test battery, CF was assessed in 138 women diagnosed with breast cancer prior to initiation of adjuvant therapy and 81 age- and education-matched controls and summarized across eight composites. Participants were genotyped for 39 functional or tagging single nucleotide polymorphisms (SNPs) of select oxidative stress (CAT, GPX1, SEPP1, SOD1, and SOD2) and DNA repair (ERCC2, ERCC3, ERCC5, and PARP1) genes. Multiple linear regression was used to determine if the presence or absence of one or more minor alleles account for variability in CF composite scores. Based on regression findings from the analysis of individual SNPs, weighted multi-gene, multi-polymorphism genetic risk scores (GRSs) were calculated to evaluate the collective effect of possession of multiple protective and/or risk alleles. Each CF composite was significantly (p < 0.05) associated with one or more oxidative stress and DNA repair gene polymorphisms evaluated either by SNP main effects and/or SNP-by-prescribed breast cancer treatment group interactions. Each computed GRS was found to be significantly (p < 0.001) related to its corresponding CF composite. All associations were positive suggesting that as overall genetic protection increases, CF composite score increases (indicating better performance). These findings suggest that genetic variation in the oxidative stress and DNA repair pathways may play an important role in pre-adjuvant therapy CF in breast cancer survivors.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Uruguay 1 3%
Unknown 36 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 19%
Student > Bachelor 6 16%
Student > Ph. D. Student 5 14%
Student > Postgraduate 4 11%
Professor > Associate Professor 4 11%
Other 6 16%
Unknown 5 14%
Readers by discipline Count As %
Medicine and Dentistry 9 24%
Psychology 5 14%
Nursing and Health Professions 4 11%
Neuroscience 4 11%
Biochemistry, Genetics and Molecular Biology 4 11%
Other 6 16%
Unknown 5 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2016.
All research outputs
#20,322,106
of 22,865,319 outputs
Outputs from SpringerPlus
#1,460
of 1,850 outputs
Outputs of similar age
#255,233
of 300,904 outputs
Outputs of similar age from SpringerPlus
#164
of 200 outputs
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