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Cannabidiol promotes browning in 3T3-L1 adipocytes

Overview of attention for article published in Molecular and Cellular Biochemistry, April 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#4 of 1,814)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
6 news outlets
twitter
44 tweeters
facebook
12 Facebook pages
video
2 video uploaders

Citations

dimensions_citation
15 Dimensions

Readers on

mendeley
75 Mendeley
Title
Cannabidiol promotes browning in 3T3-L1 adipocytes
Published in
Molecular and Cellular Biochemistry, April 2016
DOI 10.1007/s11010-016-2702-5
Pubmed ID
Authors

Hilal Ahmad Parray, Jong Won Yun

Abstract

Recruitment of the brown-like phenotype in white adipocytes (browning) and activation of existing brown adipocytes are currently being investigated as a means to combat obesity. Thus, a wide variety of dietary agents that contribute to browning of white adipocytes have been identified. The present study was designed to investigate the effects of cannabidiol (CBD), a major nonpsychotropic phytocannabinoid of Cannabis sativa, on induction of browning in 3T3-L1 adipocytes. CBD enhanced expression of a core set of brown fat-specific marker genes (Ucp1, Cited1, Tmem26, Prdm16, Cidea, Tbx1, Fgf21, and Pgc-1α) and proteins (UCP1, PRDM16, and PGC-1α). Increased expression of UCP1 and other brown fat-specific markers contributed to the browning of 3T3-L1 adipocytes possibly via activation of PPARγ and PI3K. In addition, CBD increased protein expression levels of CPT1, ACSL, SIRT1, and PLIN while down-regulating JNK2, SREBP1, and LPL. These data suggest possible roles for CBD in browning of white adipocytes, augmentation of lipolysis, thermogenesis, and reduction of lipogenesis. In conclusion, the current data suggest that CBD plays dual modulatory roles in the form of inducing the brown-like phenotype as well as promoting lipid metabolism. Thus, CBD may be explored as a potentially promising therapeutic agent for the prevention of obesity.

Twitter Demographics

The data shown below were collected from the profiles of 44 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Uruguay 1 1%
Unknown 73 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 14 19%
Researcher 10 13%
Student > Master 10 13%
Student > Ph. D. Student 10 13%
Other 5 7%
Other 8 11%
Unknown 18 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 21%
Medicine and Dentistry 10 13%
Agricultural and Biological Sciences 10 13%
Pharmacology, Toxicology and Pharmaceutical Science 6 8%
Neuroscience 3 4%
Other 10 13%
Unknown 20 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 91. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2020.
All research outputs
#244,187
of 16,028,822 outputs
Outputs from Molecular and Cellular Biochemistry
#4
of 1,814 outputs
Outputs of similar age
#7,041
of 266,858 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#1
of 30 outputs
Altmetric has tracked 16,028,822 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,814 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,858 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.