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Relationship between pathogenic, clinical, and virulence factors of Staphylococcus aureus in infective endocarditis versus uncomplicated bacteremia: a case–control study

Overview of attention for article published in European Journal of Clinical Microbiology & Infectious Diseases, March 2016
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Title
Relationship between pathogenic, clinical, and virulence factors of Staphylococcus aureus in infective endocarditis versus uncomplicated bacteremia: a case–control study
Published in
European Journal of Clinical Microbiology & Infectious Diseases, March 2016
DOI 10.1007/s10096-016-2603-2
Pubmed ID
Authors

M. M. Gallardo-García, G. Sánchez-Espín, R. Ivanova-Georgieva, J. Ruíz-Morales, I. Rodríguez-Bailón, V. Viñuela González, M. V. García-López

Abstract

Pathogenic factors of Staphylococcus aureus (SA) in the development of infective endocarditis (IE) have not been sufficiently investigated. The purpose of this study was to analyze the pathogenesis and virulence factors of SA in patients with IE as compared to patients with uncomplicated bacteremia (un-BAC). This is a retrospective case-control study (2002-2014) performed at a tertiary hospital in Spain. Clinical and epidemiological factors were analyzed. We assessed the presence of toxin genes [toxic shock syndrome toxin 1 (tst-1) and enterotoxins A (etA), B (etB), and D (etD)] and the potential relationship between accessory gene regulator (agr) groups and the development of IE confirmed by polymerase chain reaction (PCR). Twenty-nine patients with IE were compared with 58 patients with uncomplicated S. aureus bacteremia (SAB). As many as 75.9 % of patients had community-acquired IE (p < 0.005). Multivariate analysis revealed that there is a significant relationship between community-acquired infection and severe sepsis or septic shock and IE. Also, a minimum inhibitory concentration (MIC) of vancomycin ≥1.5 μg/ml was found to be associated with IE. The agr group I was prevalent (55.2 % vs. 31.0 %; p = 0.030). No association was observed between toxin genes (tst-1, etA, etB, and etD) and IE. The superantigen (SAg) most frequently found in SA isolates was tst-1 (12.6 %). We found no association between toxin genes and IE, probably due to the small sample size. However, a direct relationship was found between agr I and the development of IE, which suggests that agr I strains may have more potential to cause IE.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 24%
Student > Master 5 13%
Unspecified 4 11%
Student > Doctoral Student 4 11%
Student > Bachelor 3 8%
Other 5 13%
Unknown 8 21%
Readers by discipline Count As %
Medicine and Dentistry 12 32%
Unspecified 6 16%
Pharmacology, Toxicology and Pharmaceutical Science 5 13%
Biochemistry, Genetics and Molecular Biology 4 11%
Nursing and Health Professions 2 5%
Other 1 3%
Unknown 8 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2016.
All research outputs
#9,769,729
of 12,226,394 outputs
Outputs from European Journal of Clinical Microbiology & Infectious Diseases
#1,374
of 1,790 outputs
Outputs of similar age
#197,359
of 280,289 outputs
Outputs of similar age from European Journal of Clinical Microbiology & Infectious Diseases
#40
of 59 outputs
Altmetric has tracked 12,226,394 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,790 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.