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White fat, factitious hyperglycemia, and the role of FDG PET to enhance understanding of adipocyte metabolism

Overview of attention for article published in EJNMMI Research, June 2011
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Title
White fat, factitious hyperglycemia, and the role of FDG PET to enhance understanding of adipocyte metabolism
Published in
EJNMMI Research, June 2011
DOI 10.1186/2191-219x-1-2
Pubmed ID
Authors

Michael S Hofman, Rodney J Hicks

Abstract

The development of a hybrid PET/CT led to the recognition of the enhanced glycolysis in brown fat. We report a previously unrecognized mechanism for altered fluorodeoxyglucose (FDG) biodistribution with diffuse white adipose tissue uptake. This occurred during a restaging scan for cervical cancer following administration of insulin in the setting of measured hyperglycemia. The patient's blood sugar normalized, but she experienced symptoms and signs of hypoglycemia. A subsequent history indicated that the patient received intravenous high-dose vitamin C just prior to arrival. Ascorbic acid is a strong reducing agent and can cause erroneous false positive portable glucometer readings. Accordingly, it is likely the patient was euglycemic on arrival and was administered FDG during a period of insulin-induced hypoglycemia. Prominent diffuse white adipose tissue, gastric mucosal, myocardial, and very low hepatic and muscle activity were observed. The case provides insight into the metabolic changes that occur during hypoglycemia and the potential danger of relying on portable glucometer readings. We discuss the potential biological basis of this finding and provide recommendations on the avoidance of this complication.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Other 3 18%
Student > Bachelor 3 18%
Researcher 3 18%
Student > Postgraduate 3 18%
Student > Ph. D. Student 2 12%
Other 1 6%
Unknown 2 12%
Readers by discipline Count As %
Medicine and Dentistry 9 53%
Psychology 2 12%
Agricultural and Biological Sciences 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Computer Science 1 6%
Other 0 0%
Unknown 3 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2012.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from EJNMMI Research
#299
of 612 outputs
Outputs of similar age
#92,531
of 123,940 outputs
Outputs of similar age from EJNMMI Research
#2
of 3 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 612 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 123,940 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.