The use of leukocytes’ secretome to individually target biological therapy in autoimmune arthritis: a case report

Choice bDMARD: trial&failure? ➡️ leukos’ secretome? 24yo♀️RA/PsA DAS8 PRED MTX HCQ ADA ABA all🚫 5yrs later: anti-IL12/23 ustekinumab🚫 New: check cytokines- stimulated leuko' ⬆️IL-6 Rx tocilizumab ++Remission https://t.co/mvucyQY6je "IL6 too variable"

Having set up IL-6 assays to guide #drugdiscovery and seeing the very high inter- and intraindividual fluctuations in cytokine responses I have serious doubts that this assay is useful, despite the challenges to scale #PrecisionMedicine #Rheumatology http