WHIM Syndrome: from Pathogenesis Towards Personalized Medicine and Cure

@jfais20 Do you know what happened with the efforts to bring Plerixafor to WHIM patients? I was reviewing the efforts and run into this review - table 3: https://t.co/sKu7ZDxB1I

https://t.co/9yMoo9Jhzm "Cases of WHIM syndrome known to lack a CXCR4 mutation still have augmented agonist-induced CXCR4 signaling in neutrophils associated with impaired receptor downregulation, but the mechanism appears to involve deficient GRK express

https://t.co/9yMoo9Jhzm "WHIM syndrome is usually caused by autosomal dominant mutations in the G protein-coupled chemokine receptor CXCR4 that impair desensitization, resulting in enhanced and prolonged G protein- and β-arrestin-dependent responses."

WHIM Syndrome: from Pathogenesis towards Personalized Medicine and Cure https://t.co/9yMoo9Jhzm

WHIM Syndrome: from Pathogenesis Towards Personalized Medicine and Cure. https://t.co/X6YFnBGSSj

WHIM Syndrome: from Pathogenesis Towards Personalized Medicine and Cure. https://t.co/FUTXGXkWVI J Clin Immunol #GPCR #signaling #pharmacology