Title |
Intrahepatic cholangiocarcinoma in a patient with Wilson’s disease: a case report
|
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Published in |
Surgical Case Reports, March 2016
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DOI | 10.1186/s40792-016-0156-3 |
Pubmed ID | |
Authors |
Yosuke Mukai, Hiroshi Wada, Hidetoshi Eguchi, Daisaku Yamada, Tadafumi Asaoka, Takehiro Noda, Koichi Kawamoto, Kunihito Gotoh, Yutaka Takeda, Masahiro Tanemura, Koji Umeshita, Yumiko Hori, Eiichi Morii, Yuichiro Doki, Masaki Mori |
Abstract |
The incidence of hepatobiliary malignancies, and especially intrahepatic cholangiocarcinoma (ICC), for patients with Wilson's disease (WD), is very low, even for cirrhotic patients. A 44-year-old male was admitted to our department for treatment of a liver tumor. He was diagnosed with WD at the age of 15. According to radiological findings, his liver tumor was a suspected hepatocellular carcinoma (HCC) or a combined hepatocellular and cholangiocellular carcinoma. A partial resection of liver segments 8 (S8) and 5 (S5) was subsequently performed due to the intraoperative suspicion of intrahepatic metastasis at the surface of S5. Postoperative histology revealed that the resected portion of S8 contained an ICC; the removed S5 portion comprised a regenerative nodule with hemosiderosis. To date, the patient has survived without tumor recurrence for more than 44 months following surgery. A survey of the literature, inclusive of case reports, would suggest that surgical resection is the primary course of action for a WD patient with ICC, if liver function can be preserved and curative resection performed. |
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Student > Postgraduate | 1 | 20% |
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Medicine and Dentistry | 3 | 60% |
Biochemistry, Genetics and Molecular Biology | 1 | 20% |
Unknown | 1 | 20% |