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Characterization of an in vitro fed-batch model to obtain cells released from S. epidermidis biofilms

Overview of attention for article published in AMB Express, March 2016
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62 Mendeley
Title
Characterization of an in vitro fed-batch model to obtain cells released from S. epidermidis biofilms
Published in
AMB Express, March 2016
DOI 10.1186/s13568-016-0197-9
Pubmed ID
Authors

Angela França, Virgínia Carvalhais, Manuel Vilanova, Gerald B. Pier, Nuno Cerca

Abstract

Both dynamic and fed-batch systems have been used for the study of biofilms. Dynamic systems, whose hallmark is the presence of continuous flow, have been considered the most appropriate for the study of the last stage of the biofilm lifecycle: biofilm disassembly. However, fed-batch is still the most used system in the biofilm research field. Hence, we have used a fed-batch system to collect cells released from Staphylococcus epidermidis biofilms, one of the most important etiological agents of medical device-associated biofilm infections. Herein, we showed that using this model it was possible to collect cells released from biofilms formed by 12 different S. epidermidis clinical and commensal isolates. In addition, our data indicated that biofilm disassembly occurred by both passive and active mechanisms, although the last occurred to a lesser extent. Moreover, it was observed that S. epidermidis biofilm-released cells presented higher tolerance to vancomycin and tetracycline, as well as a particular gene expression phenotype when compared with either biofilm or planktonic cells. Using this model, biofilm-released cells phenotype and their interaction with the host immune system could be studied in more detail, which could help providing significant insights into the pathophysiology of biofilm-related infections.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 2%
Unknown 61 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 18%
Student > Ph. D. Student 9 15%
Student > Master 6 10%
Researcher 5 8%
Other 5 8%
Other 10 16%
Unknown 16 26%
Readers by discipline Count As %
Medicine and Dentistry 9 15%
Immunology and Microbiology 9 15%
Biochemistry, Genetics and Molecular Biology 8 13%
Agricultural and Biological Sciences 7 11%
Engineering 4 6%
Other 8 13%
Unknown 17 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2016.
All research outputs
#14,254,293
of 22,856,968 outputs
Outputs from AMB Express
#302
of 1,235 outputs
Outputs of similar age
#159,993
of 300,114 outputs
Outputs of similar age from AMB Express
#12
of 24 outputs
Altmetric has tracked 22,856,968 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,235 research outputs from this source. They receive a mean Attention Score of 2.8. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,114 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.