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Cytotoxic and DNA-damaging properties of glyphosate and Roundup in human-derived buccal epithelial cells

Overview of attention for article published in Archives of Toxicology, February 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#6 of 1,907)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
8 news outlets
blogs
2 blogs
policy
1 policy source
twitter
116 tweeters
facebook
66 Facebook pages
googleplus
9 Google+ users
reddit
3 Redditors

Citations

dimensions_citation
51 Dimensions

Readers on

mendeley
132 Mendeley
Title
Cytotoxic and DNA-damaging properties of glyphosate and Roundup in human-derived buccal epithelial cells
Published in
Archives of Toxicology, February 2012
DOI 10.1007/s00204-012-0804-8
Pubmed ID
Authors

Verena J. Koller, Maria Fürhacker, Armen Nersesyan, Miroslav Mišík, Maria Eisenbauer, Siegfried Knasmueller

Abstract

Glyphosate (G) is the largest selling herbicide worldwide; the most common formulations (Roundup, R) contain polyoxyethyleneamine as main surfactant. Recent findings indicate that G exposure may cause DNA damage and cancer in humans. Aim of this investigation was to study the cytotoxic and genotoxic properties of G and R (UltraMax) in a buccal epithelial cell line (TR146), as workers are exposed via inhalation to the herbicide. R induced acute cytotoxic effects at concentrations > 40 mg/l after 20 min, which were due to membrane damage and impairment of mitochondrial functions. With G, increased release of extracellular lactate dehydrogenase indicative for membrane damage was observed at doses > 80 mg/l. Both G and R induced DNA migration in single-cell gel electrophoresis assays at doses > 20 mg/l. Furthermore, an increase of nuclear aberrations that reflect DNA damage was observed. The frequencies of micronuclei and nuclear buds were elevated after 20-min exposure to 10-20 mg/l, while nucleoplasmatic bridges were only enhanced by R at the highest dose (20 mg/l). R was under all conditions more active than its active principle (G). Comparisons with results of earlier studies with lymphocytes and cells from internal organs indicate that epithelial cells are more susceptible to the cytotoxic and DNA-damaging properties of the herbicide and its formulation. Since we found genotoxic effects after short exposure to concentrations that correspond to a 450-fold dilution of spraying used in agriculture, our findings indicate that inhalation may cause DNA damage in exposed individuals.

Twitter Demographics

The data shown below were collected from the profiles of 116 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Brazil 3 2%
Australia 1 <1%
India 1 <1%
Unknown 124 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 27 20%
Student > Master 25 19%
Researcher 24 18%
Student > Ph. D. Student 16 12%
Unspecified 14 11%
Other 26 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 21%
Medicine and Dentistry 25 19%
Unspecified 19 14%
Environmental Science 17 13%
Biochemistry, Genetics and Molecular Biology 14 11%
Other 29 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 197. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2019.
All research outputs
#69,097
of 13,634,868 outputs
Outputs from Archives of Toxicology
#6
of 1,907 outputs
Outputs of similar age
#332
of 120,123 outputs
Outputs of similar age from Archives of Toxicology
#1
of 14 outputs
Altmetric has tracked 13,634,868 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,907 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 120,123 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.