Title |
Role of Notch signaling in regulating innate immunity and inflammation in health and disease
|
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Published in |
Protein & Cell, March 2016
|
DOI | 10.1007/s13238-016-0250-0 |
Pubmed ID | |
Authors |
Yingli Shang, Sinead Smith, Xiaoyu Hu |
Abstract |
The Notch signaling pathway is conserved from Drosophila to mammals and is critically involved in developmental processes. In the immune system, it has been established that Notch signaling regulates multiple steps of T and B cell development in both central and peripheral lymphoid organs. Relative to the well documented role of Notch signaling in lymphocyte development, less is known about its role in regulating myeloid lineage development and function, especially in the context of acute and chronic inflammation. In this review article, we will describe the evidence accumulated during the recent years to support a key regulatory role of the Notch pathway in innate immune and inflammatory responses and discuss the potential implications of such regulation for pathogenesis and therapy of inflammatory disorders. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | <1% |
Sweden | 1 | <1% |
Taiwan | 1 | <1% |
Unknown | 174 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 36 | 20% |
Student > Master | 26 | 15% |
Student > Bachelor | 20 | 11% |
Researcher | 19 | 11% |
Student > Postgraduate | 12 | 7% |
Other | 31 | 18% |
Unknown | 33 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 41 | 23% |
Agricultural and Biological Sciences | 30 | 17% |
Immunology and Microbiology | 21 | 12% |
Medicine and Dentistry | 19 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 5% |
Other | 15 | 8% |
Unknown | 43 | 24% |