Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway

KRAS and P53 deletion have different roles on oncogenic transformation: KRAS elevated the expression of SASP-related chemokines which contributed to proliferation through the CXCR2-dependent pathway, while P53 is required for an invasive phenotype. More: h

Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway. https://t.co/1Wh7rVXvuw