Title |
Immuno-modulatory activity of Ganoderma lucidum-derived polysacharide on human monocytoid dendritic cells pulsed with Der p 1 allergen
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Published in |
BMC Immunology, May 2011
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DOI | 10.1186/1471-2172-12-31 |
Pubmed ID | |
Authors |
Rong-Hwa Jan, Teng-Yi Lin, Ya-Chun Hsu, Shiuh-Sheng Lee, Shih-Yen Lo, Mingi Chang, Li-Kuang Chen, Yu-Li Lin |
Abstract |
Ganoderma lucidum-derived polysaccharide (PS-G) can rapidly and effectively promote the activation and maturation of immature dendritic cells (DCs), suggesting that PS-G possesses the capacity to regulate immune responses. This study aimed to clarify the immunologic effect of PS-G on monocyte-derived dendritic cells (MD-DCs) from asthmatic children allergic to house dust mites. The MD-DCs were stimulated for 24 h with the related allergen, Der p 1, in the presence or absence of PS-G. Cell surface markers and phagocytic capacity were assessed by FACS analysis, and key polarizing cytokines (IL-12 p40, IL-12 p70, IL-6, IL-23, and IL-10) were quantified. The subsequent regulatory effect of pulsed MD-DCs on naïve T cells was evaluated by determining the T-cell cytokine profile. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 39 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 15% |
Student > Bachelor | 6 | 15% |
Student > Master | 5 | 13% |
Student > Ph. D. Student | 4 | 10% |
Student > Postgraduate | 3 | 8% |
Other | 9 | 23% |
Unknown | 6 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 21% |
Medicine and Dentistry | 7 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 10% |
Veterinary Science and Veterinary Medicine | 2 | 5% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Other | 9 | 23% |
Unknown | 7 | 18% |