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Neoadjuvant Chemoradiation for Localized Adenocarcinoma of the Pancreas

Overview of attention for article published in Annals of Surgical Oncology, December 2001
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

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Citations

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173 Dimensions
Title
Neoadjuvant Chemoradiation for Localized Adenocarcinoma of the Pancreas
Published in
Annals of Surgical Oncology, December 2001
DOI 10.1007/s10434-001-0758-1
Pubmed ID
Authors

Rebekah R. White, Herbert I. Hurwitz, Michael A. Morse, Catherine Lee, Mitchell S. Anscher, Erik K. Paulson, Marcia R. Gottfried, John Baillie, Malcolm S. Branch, Paul S. Jowell, Kevin M. McGrath, Bryan M. Clary, Theodore N. Pappas, Douglas S. Tyler

Abstract

The use of neoadjuvant (preoperative) chemoradiotherapy (CRT) for pancreatic cancer has been advocated for its potential ability to optimize patient selection for surgical resection and to downstage locally advanced tumors. This article reports our experience with neoadjuvant CRT for localized pancreatic cancer. Since 1995, 111 patients with radiographically localized, pathologically confirmed pancreatic adenocarcinoma have received neoadjuvant external beam radiation therapy (EBRT; median, 4500 cGy) with 5-flourouracil-based chemotherapy. Tumors were defined as potentially resectable (PR, n = 53) in the absence of arterial involvement and venous occlusion and locally advanced (LA, n = 58) with arterial involvement or venous occlusion by CT. Five patients (4.5%) were not restaged due to death (n = 3) or intolerance of therapy (n = 2). Twenty-one patients (19%) manifested distant metastatic disease on restaging CT. Twenty-eight patients with initially PR tumors (53%) and 11 patients with initially LA tumors (19%) were resected after CRT. Histologic examination revealed significant fibrosis in all resected specimens and two complete responses. Surgical margins were negative in 72%, and lymph nodes were negative in 70% of resected patients. Median survival in resected patients has not been reached at a median follow-up of 16 months. Neoadjuvant CRT provided an opportunity for patients with occult metastatic disease to avoid the morbidity of resection and resulted in tumor downstaging in a minority of patients with LA tumors. Survival after neoadjuvant CRT and resection appears to be at least comparable to survival after resection and adjuvant (postoperative) CRT.

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2013.
All research outputs
#1,665,841
of 7,079,461 outputs
Outputs from Annals of Surgical Oncology
#362
of 1,759 outputs
Outputs of similar age
#86,952
of 283,227 outputs
Outputs of similar age from Annals of Surgical Oncology
#36
of 112 outputs
Altmetric has tracked 7,079,461 research outputs across all sources so far. This one has received more attention than most of these and is in the 64th percentile.
So far Altmetric has tracked 1,759 research outputs from this source. They receive a mean Attention Score of 4.6. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,227 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 112 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.