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Design of pH-Responsive Biomaterials to Enable the Oral Route of Hematological Factor IX

Overview of attention for article published in Annals of Biomedical Engineering, February 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (57th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

twitter
4 tweeters

Citations

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9 Dimensions

Readers on

mendeley
16 Mendeley
Title
Design of pH-Responsive Biomaterials to Enable the Oral Route of Hematological Factor IX
Published in
Annals of Biomedical Engineering, February 2016
DOI 10.1007/s10439-016-1566-x
Pubmed ID
Authors

Sarena D. Horava, Nicholas A. Peppas

Abstract

The oral administration of hematological factor IX (FIX) can offer a convenient prophylactic treatment for hemophilia B patients. pH-Responsive hydrogels based on poly(methacrylic acid)-grafted-poly(ethylene glycol) (P(MAA-g-EG)) have been engineered as delivery vehicles for FIX. In oral delivery, such hydrogel carriers protected FIX from the gastric environment and released it under intestinal conditions as demonstrated by evaluation of the loading and release of FIX. Tailoring of the hydrogel networks improved the loading of FIX within the microcarriers, which is critical for minimizing protein degradation. Optimizing the loading conditions by increasing the incubation time and using a reduced ionic strength buffer further improved the delivery potential of the microcarriers. The presence of the microcarriers significantly enhanced the oral absorption of FIX in vitro. As shown in this work, P(MAA-g-EG) microcarriers are promising candidates for the oral delivery of FIX.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 6%
Unknown 15 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 31%
Student > Ph. D. Student 3 19%
Student > Master 2 13%
Student > Doctoral Student 2 13%
Other 1 6%
Other 3 19%
Readers by discipline Count As %
Engineering 4 25%
Chemical Engineering 3 19%
Pharmacology, Toxicology and Pharmaceutical Science 3 19%
Unspecified 2 13%
Agricultural and Biological Sciences 1 6%
Other 3 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2017.
All research outputs
#7,049,255
of 13,029,564 outputs
Outputs from Annals of Biomedical Engineering
#821
of 1,299 outputs
Outputs of similar age
#108,031
of 267,594 outputs
Outputs of similar age from Annals of Biomedical Engineering
#9
of 33 outputs
Altmetric has tracked 13,029,564 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,299 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,594 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.