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Design of FLT3 Inhibitor - Gold Nanoparticle Conjugates as Potential Therapeutic Agents for the Treatment of Acute Myeloid Leukemia

Overview of attention for article published in Nanoscale Research Letters, December 2015
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1 tweeter

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28 Mendeley
Title
Design of FLT3 Inhibitor - Gold Nanoparticle Conjugates as Potential Therapeutic Agents for the Treatment of Acute Myeloid Leukemia
Published in
Nanoscale Research Letters, December 2015
DOI 10.1186/s11671-015-1154-2
Pubmed ID
Authors

Timea Simon, Ciprian Tomuleasa, Anca Bojan, Ioana Berindan-Neagoe, Sanda Boca, Simion Astilean

Abstract

Releasing drug molecules at the targeted location could increase the clinical outcome of a large number of anti-tumor treatments which require low systemic damage and low side effects. Nano-carriers of drugs show great potential for such task due to their capability of accumulating and releasing their payload specifically, at the tumor site. FLT3 inhibitor - gold nanoparticle conjugates were fabricated to serve as vehicles for the delivery of anti-tumor drugs. Lestaurtinib, midostaurin, sorafenib, and quizartinib were selected among the FLT3 inhibitor drugs that are currently used in clinics for the treatment of acute myeloid leukemia. The drugs were loaded onto nanoparticle surface using a conjugation strategy based on hydrophobic-hydrophobic interactions with the Pluronic co-polymer used as nanoparticle surface coating. Optical absorption characterization of the particles in solution showed that FLT3 inhibitor-incorporated gold nanoparticles were uniformly distributed and chemically stable regardless of the drug content. Drug loading study revealed a high drug content in the case of midostaurin drug which also showed increased stability. Drug release test in simulated cancer cell conditions demonstrated more than 56 % release of the entrapped drug, a result that correlates well with the superior cytotoxicity of the nano-conjugates comparatively with the free drug. This is a pioneering study regarding the efficient loading of gold nanoparticles with selected FLT3 inhibitors. In vitro cytotoxicity assessment shows that FLT3-incorporated gold nanoparticles are promising candidates as vehicles for anti-tumor drugs and demonstrate superior therapeutic effect comparatively with the bare drugs.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Romania 1 4%
Unknown 26 93%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 18%
Student > Master 4 14%
Student > Ph. D. Student 4 14%
Student > Doctoral Student 3 11%
Other 3 11%
Other 5 18%
Unknown 4 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 18%
Medicine and Dentistry 3 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 11%
Nursing and Health Professions 2 7%
Biochemistry, Genetics and Molecular Biology 2 7%
Other 5 18%
Unknown 8 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2016.
All research outputs
#7,798,326
of 12,429,961 outputs
Outputs from Nanoscale Research Letters
#276
of 798 outputs
Outputs of similar age
#150,217
of 277,841 outputs
Outputs of similar age from Nanoscale Research Letters
#2
of 3 outputs
Altmetric has tracked 12,429,961 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 798 research outputs from this source. They receive a mean Attention Score of 2.2. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,841 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.