Podría estar relacionado el riesgo de amputación descrito para iSGLT2 con su efecto diurético?
Could the higher rate of amputations potentially associated with #SGLT2 inhibitors be related to diuretic effect? Potier et al found a higher risk of #amputations in diuretic users compared with non-users in a French observational study https://t.co/kGqVym
RT @doctorjee: HR vs non-users 2.08. Hmmm! Lower limb events in individuals with type 2 diabetes: evidence for an increased risk associated…
HR vs non-users 2.08. Hmmm! Lower limb events in individuals with type 2 diabetes: evidence for an increased risk associated with diuretic use. - PubMed - NCBI https://t.co/cCjinuz77P
RT @DanielJDrucker: Confounding the Canagliflozin Conundrum #Diabetes #SGLT2 Increased risk (1.8-fold) for lower limb amputation with diure…
RT @DanielJDrucker: Confounding the Canagliflozin Conundrum #Diabetes #SGLT2 Increased risk (1.8-fold) for lower limb amputation with diure…
RT @DanielJDrucker: Confounding the Canagliflozin Conundrum #Diabetes #SGLT2 Increased risk (1.8-fold) for lower limb amputation with diure…
RT @DanielJDrucker: Confounding the Canagliflozin Conundrum #Diabetes #SGLT2 Increased risk (1.8-fold) for lower limb amputation with diure…
RT @DanielJDrucker: Confounding the Canagliflozin Conundrum #Diabetes #SGLT2 Increased risk (1.8-fold) for lower limb amputation with diure…
Confounding the Canagliflozin Conundrum #Diabetes #SGLT2 Increased risk (1.8-fold) for lower limb amputation with diuretics in the SURDIAGENE study @DiabetologiaJnl https://t.co/VVfZGdyj2P
【フランス前向きコホート、2型DM 1459例、7.1年 [中央値] 観察:利尿薬服用例の下肢切断・血行再建施行HRは2.08 [95%CI 1.49-2.93 vs. 非服用例]。諸因子補正後も1.49 [1.01-2.19]。リスク増加が著明だったのは下肢切断】 Diabetologia https://t.co/y1PThI5Uk7