Title |
Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica
|
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Published in |
Journal of Autism and Developmental Disorders, January 2012
|
DOI | 10.1007/s10803-011-1438-z |
Pubmed ID | |
Authors |
Mohammad H. Rahbar, Maureen Samms-Vaughan, Katherine A. Loveland, Deborah A. Pearson, Jan Bressler, Zhongxue Chen, Manouchehr Ardjomand-Hessabi, Sydonnie Shakespeare-Pellington, Megan L. Grove, Compton Beecher, Kari Bloom, Eric Boerwinkle |
Abstract |
Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case-control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p < 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Croatia | 1 | 1% |
United States | 1 | 1% |
Unknown | 83 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 14 | 16% |
Student > Ph. D. Student | 11 | 13% |
Student > Doctoral Student | 9 | 11% |
Student > Bachelor | 7 | 8% |
Researcher | 5 | 6% |
Other | 15 | 18% |
Unknown | 24 | 28% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 22 | 26% |
Psychology | 14 | 16% |
Social Sciences | 6 | 7% |
Agricultural and Biological Sciences | 3 | 4% |
Nursing and Health Professions | 3 | 4% |
Other | 11 | 13% |
Unknown | 26 | 31% |