@coco_chatel > LPS — indicator of a leaky gut Yes. #Lipopolysaccharide is a normal product of gut bacteria. However—in the bloodstream, it’s toxic. Mast cell activation increases intestinal barrier permeability, allowing #endotoxemia. This is a key f
"The resultant combination of super-oxide ions with NO results in further increases in levels of ONOO−, thereby inducing increased oxidation of BH4 to BH2, further decreasing the activity of eNOS in an escalating positive feedback loop" #MECFS https://t.c
Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop? https://t.co/cAYMxDMdIE
@ahandvanish https://t.co/aqjs2kGBFS (characterisation of HIF-1a's importance) https://t.co/BqgXcGvTBH (EBV -> warburg) https://t.co/xFP0RfSrNp (SARS1/2+MERS -> warburg) https://t.co/eSLTDjUGCv (H.pylori)
RT @renesugar: https://t.co/r0EnVOCPCX "The resultant combination of super-oxide ions with NO results in further increases in levels of ON…
https://t.co/r0EnVOCPCX "The resultant combination of super-oxide ions with NO results in further increases in levels of ONOO−, thereby inducing increased oxidation of BH4 to BH2, further decreasing the activity of eNOS in an escalating positive feedback
RT @renesugar: Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop? #MECFS https://t.co/0nT4543unY "furt…
FYI @Georgeberger
RT @ARMoore864: @EnergyCommerce @RepAnnaEshoo @FrankPallone @GOPHELP @HELPCmteDems When will the funding for #MECFS be increased by a facto…
RT @ARMoore864: @EnergyCommerce @RepAnnaEshoo @FrankPallone @GOPHELP @HELPCmteDems When will the funding for #MECFS be increased by a facto…
@EnergyCommerce @RepAnnaEshoo @FrankPallone @GOPHELP @HELPCmteDems When will the funding for #MECFS be increased by a factor of 25? Covid Longhaulers and millions of others have NO TREATMENT due to the NEGLIGENCE of the @nih @NINDSdirector @NINDSfunding
RT @renesugar: Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop? #MECFS https://t.co/0nT4543unY "furt…
RT @renesugar: https://t.co/Z0UGtEooed "The GSH and thioredoxin systems are progressively inactivated in an environment of increasing chro…
@Sabrina_Poirier @CIHR_IMHA @KarimKhan_IMHA Ivabradine reduces the calcium leak in RyR2. Dantrolene is another drug that reduces the calcium leak in RyR1. A loop where ROS (eg. from exercise) results in more calcium released affecting mitochondria result
@MEAssociation ROS cause ryanodine receptors to leak calcium into the cell impairing mitochondria leading to the release of even more ROS. #MECFS https://t.co/CZNCRlV5Ko https://t.co/n6i2asTjyl https://t.co/Z0UGtEooed https://t.co/1jqaQHPmoS https://t
Ryanodex (RyR1/RyR2) + Metformin (lowers TGF-β1) https://t.co/n6i2asTjyl https://t.co/h58eojtjNC https://t.co/Z0UGtEooed https://t.co/BC4a1GtNEA https://t.co/tV0Eg4hHat https://t.co/phUJ3UIV66 https://t.co/8uc3u698a1 https://t.co/QDV8Wh9enB https:
https://t.co/Z0UGtEooed "The GSH and thioredoxin systems are progressively inactivated in an environment of increasing chronic ONS leading to the inhibition of denitrosylation and transnitrosylation and a state of protein ‘hypernitrosylation’" #MECFS
Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop? #MECFS https://t.co/0nT4543unY "further increases in O&NS lead to impaired activity of denitrosylases such as the thioredoxin system ... described as hypernitrosyla
@kuriozorinj @design4services @TrustCooker @PaulGarnerWoof "Early results indicate that increased production of intracellular nuclear-factor 6B and cyclo-oxygenase-2 (COX-2) may be key phenomena in CFS indicating activation of immune-inflammatory pathways
@erikmoldwarrior This paper is very good for your mould theory https://t.co/d0ckwlQTuK
Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop? https://t.co/xGTHNFY2jE
@NIHDirector @StanfordMed @OpenMedF @JanetDafoe @NINDSdirector @PlzSolveCFS @MEActNet @LBatemanMD @ngklimas @KaiserME INCREASED BY A FACTOR OF 25. 25! Do the math. Metabolic Brain Disease, April 2019: "If federal research funding for ME/CFS were to ta
RT @CatEye0611: #ME / #CFS : how cld the illness develop? “in this paper how this relatively simple 🤔😬 concept leads to a novel explanator…
RT @CatEye0611: #ME / #CFS : how cld the illness develop? “in this paper how this relatively simple 🤔😬 concept leads to a novel explanator…
#ME / #CFS : how cld the illness develop? “in this paper how this relatively simple 🤔😬 concept leads to a novel explanatory model explaining the major biological observations.” #MEresearch @OpenMedF @Invest_in_ME @MEResearchUK https://t.co/PeozNx
RT @MEActNet: A new paper is available. Strong evidence ME is "associated with a wide range of biological abnormalities, most notably in t…
RT @CatEye0611: #ME #CFS paper (#science summary) listing “strong evidence ... wide range of biological abnormalities, most notably in the…
RT @CatEye0611: #ME #CFS paper (#science summary) listing “strong evidence ... wide range of biological abnormalities, most notably in the…
RT @CatEye0611: #ME #CFS paper (#science summary) listing “strong evidence ... wide range of biological abnormalities, most notably in the…
#ME #CFS paper (#science summary) listing “strong evidence ... wide range of biological abnormalities, most notably in the #neuroendocrine, #autonomic, #neurological, #bioenergetic, #redox and #immunological domains.” https://t.co/PeozNxQTW0
RT @8Homeslice8: @Rheumatology_Dr @DrFrancesRyan @Dr_M_Guthridge This also provides a recent summary of biomedical research findings: https…
RT @8Homeslice8: @Rheumatology_Dr @DrFrancesRyan @Dr_M_Guthridge This also provides a recent summary of biomedical research findings: https…
@Rheumatology_Dr @DrFrancesRyan @Dr_M_Guthridge This also provides a recent summary of biomedical research findings: https://t.co/G410lsvtlb
Chronic fatigue syndrome: how could the illness develop? https://t.co/wh8Vif8XyR
RT @MEActNetAu: *** New Australian research*** ”Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?” Auth…
RT @MEActNetAu: *** New Australian research*** ”Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?” Auth…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
@BiomedicsMECFS https://t.co/oGWJmtPcPJ, https://t.co/RMINhpXc9n, https://t.co/q3w33QIodq, https://t.co/8IYReESf4k Mitochondrial dysfunction may to cause or consequence of ME/CFS. Novel new diagnostics identifying ETC abnormalities & subtypes is an a
RT @MEActNetAu: *** New Australian research*** ”Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?” Auth…
RT @MEActNetAu: *** New Australian research*** ”Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?” Auth…
RT @MEActNetAu: *** New Australian research*** ”Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?” Auth…
*** New Australian research*** ”Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?” Authors: Morris, Maes, Berk & Puri This article is open access: https://t.co/pINT14CXZE #mecfs
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @soltysik_rob: - Please go away. - "Hence it is difficult to conclude that persistent or chronic infections are at the root of CFS/ME/S…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
- Please go away. - "Hence it is difficult to conclude that persistent or chronic infections are at the root of CFS/ME/SEID, but of course they could be in some patients." https://t.co/6UpT9c66aM
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @MEActNet: A new paper is available. Strong evidence ME is "associated with a wide range of biological abnormalities, most notably in t…
Nice to see Dr Puri and Gerwyn Morris publishing more research. Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop? https://t.co/vOp6pXSJTE
Love to send that to the neurologist who recently asked me to hold my arms out straight in front of me & then wrote. “No signs of fatigue” in my report, despite fact I was in a wheelchair & she didn’t even ask me to stand up! Aaarghh!!
RT @MEActNet: A new paper is available. Strong evidence ME is "associated with a wide range of biological abnormalities, most notably in t…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
RT @Dr_M_Guthridge: What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in…
What causes so many biological abnormalities (neuroendocrine, autonomic, neurological, bioenergetic, redox, immune) in #MECFS? this review examines the role that #oxidative stress in promoting #inflammation in #pwME #chronicillness https://t.co/2GZBBgfm
RT @MEActNet: A new paper is available. Strong evidence ME is "associated with a wide range of biological abnormalities, most notably in t…
RT @MEActNet: A new paper is available. Strong evidence ME is "associated with a wide range of biological abnormalities, most notably in t…
RT @MEActNet: A new paper is available. Strong evidence ME is "associated with a wide range of biological abnormalities, most notably in t…