Use of Mortality as an Endpoint in Noninferiority Trials May Lead to Ethically Problematic Conclusions

@howardm19 Yes! And: https://t.co/EupRzPC2eo

RT @medevidenceblog: Recently there was talk about #noninferiority trials for #criticalcare utilizing #mortality as an endpoint. In this p…

RT @medevidenceblog: What do you do if a journal misspells your name, preventing a paper from showing up in indexes like Pubmed? @andrewmhe…

Recently there was talk about #noninferiority trials for #criticalcare utilizing #mortality as an endpoint. In this paper (which I couldn't find b/c name spelled wrong), we discuss why this is ethically problematic https://t.co/HRv0B24yxV https://t.co/5KW

What do you do if a journal misspells your name, preventing a paper from showing up in indexes like Pubmed? @andrewmhersh https://t.co/7hSk7Z2Tjg #abberegg

RT @Ricky_Turgeon: As non-inferiority trials (NI-RCTs) become more prevalent, their methods also seem to be getting laxer & less logical. T…

RT @Ricky_Turgeon: As non-inferiority trials (NI-RCTs) become more prevalent, their methods also seem to be getting laxer & less logical. T…

As non-inferiority trials (NI-RCTs) become more prevalent, their methods also seem to be getting laxer & less logical. This is another example of the idiosyncrasies of these trials: interventions that increase mortality yet concluded to be non-inferior

RT @OslerCast: Another good article relevant here: https://t.co/1yliYaYk5P "Use of Mortality as an Endpoint in Noninferiority Trials May Le…

Another good article relevant here: https://t.co/1yliYaYk5P "Use of Mortality as an Endpoint in Noninferiority Trials May Lead to Ethically Problematic Conclusions" by Andrew Hersh, Robert Walter and @medevidenceblog in @JournalGIM

It's like your dad taught you--you have to use the right tool for the job. 'Use of Mortality as an Endpoint in Noninferiority Trials May Lead to Ethically Problematic Conclusions' @andrewmhersh @BrookeArmyMed https://t.co/VCBhdApfvE https://t.co/hpXY9DjjHC

Interesting paper on morality of non-inferiority trials when using mortality as an endpoint. Seems the burden of equipoise should be stricter or other benefits alternative should very clearly outweigh the standard of treatment. Courtesy of @adamcifu https:

RT @medevidenceblog: Our latest paper on #noninferiority this time focusing on #ethics of mortality as an endpoint. Can be accessed free (b…

RT @medevidenceblog: Our latest paper on #noninferiority this time focusing on #ethics of mortality as an endpoint. Can be accessed free (b…

RT @medevidenceblog: Our latest paper on #noninferiority this time focusing on #ethics of mortality as an endpoint. Can be accessed free (b…

of likely interest, @MatthewWynia

RT @medevidenceblog: Our latest paper on #noninferiority this time focusing on #ethics of mortality as an endpoint. Can be accessed free (b…

Our latest paper on #noninferiority this time focusing on #ethics of mortality as an endpoint. Can be accessed free (but not downloaded) here: https://t.co/zi0DzNtmwS @EMNerd_ @andrewmhersh https://t.co/COPKReLjfZ

RT @JournalGIM: Use of Mortality as an Endpoint in Noninferiority Trials May Lead to Ethically Problematic Conclusions https://t.co/bEKHVOy…

Use of Mortality as an Endpoint in Noninferiority Trials May Lead to Ethically Problematic Conclusions https://t.co/bEKHVOysio