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Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation

Overview of attention for article published in AAPS PharmSciTech, July 2015
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1 tweeter
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Citations

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Readers on

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278 Mendeley
Title
Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation
Published in
AAPS PharmSciTech, July 2015
DOI 10.1208/s12249-015-0360-7
Pubmed ID
Authors

Hemlata Patil, Roshan V. Tiwari, Michael A. Repka

Abstract

Hot-melt extrusion (HME) is a promising technology for the production of new chemical entities in the developmental pipeline and for improving products already on the market. In drug discovery and development, industry estimates that more than 50% of active pharmaceutical ingredients currently used belong to the biopharmaceutical classification system II (BCS class II), which are characterized as poorly water-soluble compounds and result in formulations with low bioavailability. Therefore, there is a critical need for the pharmaceutical industry to develop formulations that will enhance the solubility and ultimately the bioavailability of these compounds. HME technology also offers an opportunity to earn intellectual property, which is evident from an increasing number of patents and publications that have included it as a novel pharmaceutical formulation technology over the past decades. This review had a threefold objective. First, it sought to provide an overview of HME principles and present detailed engineered extrusion equipment designs. Second, it included a number of published reports on the application of HME techniques that covered the fields of solid dispersions, microencapsulation, taste masking, targeted drug delivery systems, sustained release, films, nanotechnology, floating drug delivery systems, implants, and continuous manufacturing using the wet granulation process. Lastly, this review discussed the importance of using the quality by design approach in drug development, evaluated the process analytical technology used in pharmaceutical HME monitoring and control, discussed techniques used in HME, and emphasized the potential for monitoring and controlling hot-melt technology.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 278 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ireland 1 <1%
Saudi Arabia 1 <1%
Unknown 276 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 67 24%
Student > Ph. D. Student 67 24%
Unspecified 34 12%
Student > Bachelor 32 12%
Researcher 24 9%
Other 54 19%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 98 35%
Unspecified 42 15%
Medicine and Dentistry 34 12%
Engineering 26 9%
Chemistry 25 9%
Other 53 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2016.
All research outputs
#5,153,759
of 7,187,728 outputs
Outputs from AAPS PharmSciTech
#190
of 333 outputs
Outputs of similar age
#204,394
of 320,713 outputs
Outputs of similar age from AAPS PharmSciTech
#9
of 23 outputs
Altmetric has tracked 7,187,728 research outputs across all sources so far. This one is in the 24th percentile – i.e., 24% of other outputs scored the same or lower than it.
So far Altmetric has tracked 333 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,713 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.